Prognostic Factor Research of Sensory Profiles in Development of Central Sensitization

Sensory Profiles as Predictors of Central Sensitization in Low Back Pain: A Prospective Cohort Study.

A longitudinal observational cohort study to investigate the value of prognostic factors, here sensory profiles , and others, in the development of central sensitization in the low back pain population. A type 2 prognostic factor research following the PROGRESS framework. Sensory profiles are identified a prognostic factors which can predict the development of central sensitization in the low back pain population.

After performing an univariable linear regression analyses the regression model predicts the dependent variable, central sensitization, significantly, and the models are significant prediction factors of the development of central sensitization. In unadjusted analyses, all four sensory profiles were significantly associated with the development of central sensitization (P<0.001).

After adjusting for pain, disability, age, and duration of low back pain, baseline sensory profiles remained significant predictors of central sensitization. On the other hand, all other predictor variables did not contribute to the prediction of central sensitization.

Inclusion Criteria:

• acute low back pain (< 6 weeks)
• with or without radiating pain
• aged 18 to 60 years
• a pain-free episode for at least 3 months before the onset of their current back pain
• read and understand the Dutch language.

Exclusion Criteria:

• previous lumbar spinal surgery
• lumbar radicular syndrome
• specific cause of low back pain
• lumbar spinal stenosis
• current malignancy
• spondyloarthropathy
• osteoporosis
• spondylolisthesis
• major trauma
• infection
• systemic disease.