A Study to Assess CT-868 and the Relationship Between Insulin Secretory Response and Ambient Blood Glucose

A Randomized, Double-Blind, Placebo and Comparator-Controlled Crossover Study to Assess Pharmacokinetic and Pharmacodynamic Effects of CT-868 on the Relationship Between Insulin Secretory Response and Ambient Blood Glucose in Obese Male Subjects and Subjects with T2DM

A Study to Assess the Effect of CT-868 and the Relationship Between Insulin Secretory Response and Ambient Blood Glucose in Obese Male Subjects and Subjects with T2DM.

Inclusion Criteria:

• Part 1: Obese Otherwise Healthy Males
• Part 2: Males or Females with T2D
• Part 1: BMI 30.0-35.0, inclusive
• Part 2: BMI 27.0-45.0, inclusive
• 18-65 years old, inclusive
• Stable body weight for 2 months

Exclusion Criteria:

• Significant medical history
• Uncontrolled hypertension
• History of malignancy