Not provided
Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| NCI-2021-06438 | Registry Identifier | CTRP (Clinical Trial Reporting Program) |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
This study examines how electronic (e)-cigarette use impacts the body, by studying both users and non-users of e-cigarettes. Early evidence indicates that e-cig users experience adverse health effects. Results of this study may help policy-makers develop standards for different types of tobacco.
PRIMARY OBJECTIVE:
Examine the short-term impacts of vaping on pulmonary and respiratory outcomes.
OUTLINE:
Current e-cigarette users will vape their own e-cigarette device ad libitum for 30 minutes; non-users will watch a neutral video for 30 minutes. Before and after the 30 minute vaping [video] session, participants will undergo the following assessments: computer-based spirometry testing, nitric oxide breath testing, airwave oscillometry, and an assessment of endothelial function. Participants will also undergo collection of blood.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Prevention (survey, breathe tests, biospecimen collection) | Participants undergo computer-based spirometry testing, nitric oxide breath testing, airwave oscillometry, and an assessment of endothelial function. Participants will undergo collection of blood. Current e-cigarette users also vape their own e-cigarette device for 30 minutes. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Biospecimen Collection | Procedure | Undergo collection of blood |
|
| Measure | Description | Time Frame |
|---|---|---|
| Airway inflammation as assessed by exhaled nitric oxide | Exhaled nitric oxide will be measured in parts per billion (ppb) | Procedure will last approximately 3 minutes; the procedure will occur twice during the laboratory session (separated by approximately 60 minutes) |
| Airway reactivity as assessed by airwave oscillometry | Airway reactivity will be measured via Tremoflo, which is a well validated measurement of airway reactivity and provides curves of Resistance (R) and Reactance (X) | Procedure will last approximately 3 minutes; the procedure will occur twice during the laboratory session (separated by approximately 60 minutes) |
| Respiratory functioning as assessed by a mobile Spirometry device | Spirometry will collect daily data from participants on the relationship between their forced expiratory volume and forced vital capacity (measured as FEV1/FVC). | Procedure will last approximately 3 minutes; the procedure will occur twice during the laboratory session (separated by approximately 60 minutes) |
| Endothelial function | Endothelial function will be assessed with the EndoPAT device (unit of measurement = LnRHI). | Procedure will last approximately 20 minutes; the procedure will occur twice during the laboratory session (separated by approximately 90 minutes) |
Not provided
Not provided
Inclusion Criteria:
Not provided
Not provided
E-cig (cigarette) users and non-users in Ohio
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Megan E Roberts, PhD | Ohio State University Comprehensive Cancer Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | United States |
Not provided
| Label | URL |
|---|---|
| The Jamesline | View source |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D009991 | Oscillometry |
| ID | Term |
|---|---|
| D008919 | Investigative Techniques |
Not provided
Not provided
Not provided
Not provided
Not provided
Blood
| Nitric Oxide Breath Test | Procedure | Undergo nitric oxide breath testing |
|
| Oscillometry | Procedure | Undergo airwave oscillometry |
|
| Spirometry | Procedure | Undergo spirometry |
|
| Survey Administration | Other | Complete survey |
|
| Endothelial function | Procedure | Endothelial function will be assessed with the EndoPAT device, which measures changes in pressure from sensors placed on the fingertip |
|