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The gender, age, ICU diagnosis, basic diseases, antibiotic treatment plan, physiological indicators, duration of hospital stay, length of stay in ICU, hospitalization cost, prognosis and other discharge information of patients receiving tigecycline or polymyxin B admitted to the ICU of four provincial-level Grade A hospitals in Changsha, Hunan Province ,China from 2017 to 2021 were included.
To analyze the therapeutic effect of tigecycline-based or polymyxin B-based antibiotic regimens and their effect on the prognosis of patients, and to conduct subgroup analysis.
The gender, age, ICU diagnosis, basic diseases, antibiotic treatment plan, physiological indicators, duration of hospital stay, length of stay in ICU, hospitalization cost, prognosis and other discharge information of patients receiving tigecycline or polymyxin B admitted to the ICU of four provincial-level Grade A hospitals in Changsha, Hunan Province ,China from 2017 to 2021 were included. The four hospitals included the 1st-3th XiangYa Hospitals and Hunan Provincial People's Hospital. Organize the data.Patients with a course of treatment < 4 days and shedding were excluded.To analyze the therapeutic effect of tigecycline-based or polymyxin B-based antibiotic regimens and their effect on the prognosis of patients, and to conduct subgroup analysis. The chi-square test was used for the counting data, and the Mann-Whitney U test or Kruskal-Wallis H test was used for the measurement data. The significance value was adjusted by Bonferroni correction method for multiple tests, and the P was tested on both sides,P>0.05.
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| Measure | Description | Time Frame |
|---|---|---|
| hospital mortality rate | Patients die in hospital or abandon treatment due to poor prognosis in hospital after treatment of tigecycline or polymyxin B | up to hospital discharge or die in hospital, up to 48 weeks(estimation). |
| 30d mortality rate | Patients die after treatment of tigecycline or polymyxin B | up to the 30th day of the treatment of tigecycline or polymyxin B |
| Bacterial clearance rate | Bacterial clearance during treatment of tigecycline or polymyxin B | from the first day of the treatment of tigecycline or polymyxin B until to the end day, up to 8 weeks (estimation). |
| Measure | Description | Time Frame |
|---|---|---|
| The length of hospital stay | The length of hospital stay,days | up to hospital discharge or die in hospital, up to 48 weeks (estimation). |
| The length of ICU stay | The length of ICU stay |
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Inclusion Criteria:
Exclusion Criteria:
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14-95 year-old patients in ICU, who received tigecycline and polymyxin B treatment (≥4d).
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Shuangping Zhao | Contact | 13974953002 | zsping8888@sina.cn |
| Name | Affiliation | Role |
|---|---|---|
| Shuangping Zhao | Xiangya Hospital of Central South University | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Xiangya Hospital of Central south university | Recruiting | Changsha | Hunan | China |
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| up to hospital discharge or die in hospital, up to 24 weeks (estimation). |
| Hospitalization Cost | total Hospitalization Cost | up to hospital discharge or die in hospital, up to 48 weeks (estimation). |
| serum creatinine | serum creatinine at the end day of the treatment of tigecycline or polymyxin B | at the end day of the treatment of tigecycline or polymyxin B, up to 8 weeks (estimation). |
| MV days | the total days with mechanical ventilation | up to hospital discharge or die in hospital, up to 48 weeks (estimation). |
| VA days | the total days with vasoactive agent | up to hospital discharge or die in hospital, up to 48 weeks (estimation). |