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Purpose: To investigate intravitreal aflibercept (IVA) injection as an adjunctive treatment to trabeculectomy with mitomycin C (TMC) and panretinal photocoagulation (PRP) for neovascular glaucoma (NVG).
Setting: Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand Study design: Prospective interventional case series Methods: PRP and IVA (2 mg/0.05 ml) injection were given, and TMC was performed within 2 weeks after IVA. Additional PRP, laser suture lysis, subconjunctival 5-fluorouracil injection, and bleb needling were performed after TMC if indicated. Best-collected visual acuity (BCVA), intraocular pressure (IOP), surgical complications, and number of anti-glaucoma medications were collected.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Aflibercept Ophthalmic | Drug | Panretinal photocoagulation and intravitreal aflibercept (2 mg/0.05 ml) injection were given, and trabeculectomy with mitomycin C was performed within 2 weeks after intravitreal aflibercept injection. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Intraocular pressure | Intraocular pressure after trabeculectomy | Post-operative on day 1st |
| Intraocular pressure | Intraocular pressure after trabeculectomy | Post-operative on day 7th |
| Intraocular pressure | Intraocular pressure after trabeculectomy | Post-operative on month 3rd |
| Intraocular pressure | Intraocular pressure after trabeculectomy | Post-operative on month 6th |
| Intraocular pressure | Intraocular pressure after trabeculectomy | Post-operative on month 12th |
| Intraocular pressure | Intraocular pressure after trabeculectomy | Post-operative on month 18th |
| Intraocular pressure | Intraocular pressure after trabeculectomy | Post-operative on month 24th |
| Intraocular pressure | Intraocular pressure after trabeculectomy | Post-operative on month 30th |
| Intraocular pressure |
| Measure | Description | Time Frame |
|---|---|---|
| Visual acuity | Visual acuity of the studied eye | Post-operative on day 1st |
| Visual acuity | Visual acuity of the studied eye | Post-operative on day 7th |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Naris Kitnarong | Bangkoknoi | Bangkok | 10700 | Thailand |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25812531 | Result | Kitnarong N, Sriyakul C, Chinwattanakul S. A Prospective Study to Evaluate Intravitreous Ranibizumab as Adjunctive Treatment for Trabeculectomy in Neovascular Glaucoma. Ophthalmol Ther. 2015 Jun;4(1):33-41. doi: 10.1007/s40123-015-0033-3. Epub 2015 Mar 27. | |
| 18425438 | Result | Kitnarong N, Chindasub P, Metheetrairut A. Surgical outcome of intravitreal bevacizumab and filtration surgery in neovascular glaucoma. Adv Ther. 2008 May;25(5):438-43. doi: 10.1007/s12325-008-0047-5. |
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Centers who collect the data of neovascular Glaucoma patients who underwent intravitreal aflibercept injection, pan retinal photocoagulation and trabeculectomy with mitomycin C.
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| ID | Term |
|---|---|
| D015355 | Glaucoma, Neovascular |
| ID | Term |
|---|---|
| D005901 | Glaucoma |
| D009798 | Ocular Hypertension |
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| D014130 | Trabeculectomy |
| ID | Term |
|---|---|
| D018463 | Filtering Surgery |
| D013508 | Ophthalmologic Surgical Procedures |
| D013514 | Surgical Procedures, Operative |
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Intraocular pressure after trabeculectomy |
| Post-operative on month 36th |
| Visual acuity | Visual acuity of the studied eye | Post-operative on month 3rd |
| Visual acuity | Visual acuity of the studied eye | Post-operative on month 6th |
| Visual acuity | Visual acuity of the studied eye | Post-operative on month 12th |
| Visual acuity | Visual acuity of the studied eye | Post-operative on month 18th |
| Visual acuity | Visual acuity of the studied eye | Post-operative on month 24th |
| Visual acuity | Visual acuity of the studied eye | Post-operative on month 30th |
| Visual acuity | Visual acuity of the studied eye | Post-operative on month 36th |
| Numbers of medication | Numbers of anti-glaucoma medications | Post-operative on month12th |
| Numbers of medication | Numbers of anti-glaucoma medications | Post-operative on month 24th |
| Numbers of medication | Numbers of anti-glaucoma medications | Post-operative on month 36th |
| 25580888 | Result | Kobayashi S, Inoue M, Yamane S, Sakamaki K, Arakawa A, Kadonosono K. Long-term Outcomes After Preoperative Intravitreal Injection of Bevacizumab Before Trabeculectomy for Neovascular Glaucoma. J Glaucoma. 2016 Mar;25(3):281-4. doi: 10.1097/IJG.0000000000000211. |