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To date, there are no studies of the therapeutic effects of varied work-focused programs in Veterans undergoing outpatient substance use disorder (SUD) treatment. The investigators propose a randomized clinical trial to test the effects of work-focused programs on improving sobriety and other clinical outcomes in Veterans early in the course of recovery from SUD. Veterans will be randomized to either receive or not receive referral for work-focused therapeutic programs. Primary aim is to examine effects of work-focused programs on sobriety outcomes, namely sobriety and global functioning. Secondary aim is to examine effects of work-focused programs on psychiatric symptoms, self esteem/efficacy, and quality of life.
The investigators propose a trial to test the effects of Incentive Therapy (IT) and Other Therapeutic and Supported Employment Services (Other TSES) on improving SUD outcomes in newly recovering Veterans in outpatient treatment. In line with eligibility criteria for different TSES programs, the investigators will employ a two branch study: One branch will be for Veterans who are not interested in pursuing competitive employment, and will be a two arm RCT with randomization (2:1) to referral for IT + treatment as usual (TAU; including usual SUD outpatient treatment) or TAU alone. The second branch will be for Veterans who express interest in competitive employment, and will be a two arm RCT with randomization (2:1) to referral for TSES competitive employment services + TAU or TAU alone. Total Intent to Treat sample will be 140 (n=70 per branch). Primary outcomes will be percent days abstinent during 3 month active phase and clinical global impression scale scores at 6 months. Secondary outcome will be psychiatric symptoms, self esteem/efficacy and quality of life.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| treatment as usual | Active Comparator | usual substance use treatment |
|
| treatment as usual plus referral to work focused program | Experimental | usual substance use treatment plus referral to a competitive or non-competitive work-focused program |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| referral to work focused program | Behavioral | referral to Incentive Therapy or to Other Therapeutic and Supported Employment Services |
|
| Measure | Description | Time Frame |
|---|---|---|
| percent days abstinent | percent days abstinent during 3-month active phase | 3 months |
| Clinical Global Impression | Clinical Global Impression ratings conducted at 6 months from study entry. | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| change from baseline in BASIS-24 | change in Behavior and Symptom Identification Scale, self-report | 3 months |
| change from baseline in Rosenberg self-esteem scale | change in self report of self-esteem |
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Inclusion Criteria:
Participants will be Veterans enrolled in VACHS substance use treatment, who at time of consenting into the study are within 30 days of detoxification or last substance use as per medical record.
Additional criteria will be as follows:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Joanna M. Fiszdon, PhD | VA Connecticut Healthcare System West Haven Campus, West Haven, CT | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| VA Connecticut Healthcare System West Haven Campus, West Haven, CT | West Haven | Connecticut | 06516-2770 | United States |
De-identified, anonymized dataset will be created. This dataset may be shared with other investigators, upon written request, under a data use agreement prohibiting the recipient from identifying or re-de-identifying (or taking steps to identify or re-identify) any individual whose data are included in the dataset. The data sharing agreement will also restrict redistribution to third parties and proper acknowledgment of the data source. These datasets will be shared per guidelines provided by VACHS Information Security Officer.
After study completion
After study completion for no less than 7 years.
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| ICF | No | No | Yes | Informed Consent Form | May 20, 2021 | Sep 11, 2025 | ICF_000.pdf |
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| ID | Term |
|---|---|
| D019966 | Substance-Related Disorders |
| ID | Term |
|---|---|
| D064419 | Chemically-Induced Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D013812 | Therapeutics |
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Two branch study: one branch for Vets not interested in competitive employment, and one for Vets interested in competitive employment. Within each branch, Veterans will be randomized to either treatment as usual, or treatment as usual plus referral to competitive or non-competitive work-focused program.
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Assessors will be blind to randomization status.
| treatment as usual | Other | usual treatment |
|
| 6 months |
| change from baseline in New General Self-Efficacy Scale | change in self-report of self-efficacy | 6 months |
| change in WHOQOL BREF | change in self-report of quality of life | 6 months |