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Explore The Mechanism for the Effects of Joint Biomechanical Properties on Medial Cartilage of Tibiofemoral Joint Degeneration
Cartilage degeneration in the medial tibiofemoral joint is common after anterior cruciate ligament reconstruction (ACLR), which may develop into knee osteoarthritis (disability rate 21.3%). Alterations in joint biomechanical properties play an important role in cartilage degeneration after ACLR. However, the mechanism remains unclear.
Our research studied the joint kinematics and kinetics properties after ACLR and found significant changes in biomechanics in the ACLR knees. Therefore, this study will combine longitude biochemical changes in the cartilage to explore how the alterations in biomechanics would influence biochemical changes in the joint cartilage.
This study will explore the joint biomechanical properties during functional activities by motion analysis, the effects of biomechanical properties on cartilage stress distribution by finite element analysis, the long-term biochemical changes in the joint cartilage by functional MRI. This study will establish prediction models for cartilage biomechanical changes in the mid-term based on joint biomechanical properties in the early stage after ACLR, and cartilage biomechanical changes in the long-term based on joint biomechanical properties in the mid-term after ACLR. The study aims to clarify the mechanism of cartilage degeneration after ACLR and search biomechanical risk factors, in order to provide methods for clinical prevention of cartilage degeneration after ACLR.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| healthy volunteers | gait testing and MRI at baseline for healthy volunteers |
| |
| ACL-deficient patients | gait testing and MRI at pre-operation, 6 months post-operation, 1 year post-operation, 2 years post-operation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| gait testing, functional MRI | Diagnostic Test | diagnostic tests including the gait testing and functional MRI |
|
| Measure | Description | Time Frame |
|---|---|---|
| knee T1 rho value | knee T1 rho value by functional MRI | On the day of enrollment. |
| knee T1 rho value | knee T1 rho value by functional MRI | At 6 months post operation. |
| knee T1 rho value | knee T1 rho value by functional MRI | At 12 months post operation. |
| knee T1 rho value | knee T1 rho value by functional MRI | At 2 years post operation. |
| knee T2 value | knee T1 rho value by functional MRI | On the day of enrollment. |
| knee T2 value | knee T1 rho value by functional MRI | At 6 months post operation. |
| knee T2 value | knee T1 rho value by functional MRI | At 12 months post operation. |
| knee T2 value | knee T1 rho value by functional MRI | At 2 years post operation. |
| knee extension angles |
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Inclusion Criteria:
Unilateral ACL rupture of the knee
Exclusion Criteria:
concomitant with other ligament injury or rupture, with history of surgery or musculoskeletal system injury of the contralateral knee, and the time from injury to operation more than 8 weeks
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Thirty patients with ACL rupture undergoing ACL reconstruction surgery at the Institute of Sports Medicine, Peking University Third Hospital would be included in the study cohort were included, A total of 30 healthy volunteers with no history of musculoskeletal system injury or surgery in bilateral lower extremities would be included
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Shuang Ren | Contact | +8617610252992 | xixishuang123@126.com |
| Name | Affiliation | Role |
|---|---|---|
| Shuang Ren | Peking University Third Hospital | Principal Investigator |
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| ID | Term |
|---|---|
| D000070598 | Anterior Cruciate Ligament Injuries |
| ID | Term |
|---|---|
| D007718 | Knee Injuries |
| D007869 | Leg Injuries |
| D014947 | Wounds and Injuries |
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| ID | Term |
|---|---|
| D008279 | Magnetic Resonance Imaging |
| ID | Term |
|---|---|
| D014054 | Tomography |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping
| On the day of enrollment. |
| knee extension angles | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | At 6 months post operation. |
| knee extension angles | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | At 12 months post operation. |
| knee extension angles | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | At 2 years post operation. |
| knee moments | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | On the day of enrollment. |
| knee moments | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | At 6 months post operation. |
| knee moments | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | At 12 months post operation. |
| knee moments | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | At 2 years post operation. |
| ground reaction force | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | On the day of enrollment. |
| ground reaction force | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | At 6 months post operation. |
| ground reaction force | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | At 12 months post operation. |
| ground reaction force | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | At 2 years post operation. |
| knee rotation angles | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | On the day of enrollment. |
| knee rotation angles | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | At 6 months post operation. |
| knee rotation angles | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | At 12 months post operation. |
| knee rotation angles | Three-dimensional gait analysis system and plantar pressure were used during walking, running, cutting and jumping | At 2 years post operation. |