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| ID | Type | Description | Link |
|---|---|---|---|
| R61MH125130 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| William Marsh Rice University | OTHER |
| National Institute of Mental Health (NIMH) | NIH |
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Previous work by the study group convinced the study team to pursue development of focused cognitive reappraisal training as a novel approach to treatment of BPD, either as stand-alone treatment or in concert with evidence-based treatments of BPD. The present proposal aims to refine and test a proposed clinical intervention for BPD patients, training in reappraisal-by-distancing, in terms of its ability to influence hypothesized neural and behavioral targets and, once that is established, to demonstrate its ability improve clinically relevant outcome measures.
Borderline Personality Disorder (BPD) is a prevalent, enduring and disabling psychiatric condition found in approximately 2% to 5.9% of the population and 20% of hospitalized psychiatric patients. Suicide rates of approximately 10% have been reported. One of the most prominent clinical features of BPD is extreme mood shifts occurring in response to external social/emotional events. The emotional instability in BPD contributes to many of the most disabling, even life-threatening, symptoms of the disorder, including suicidality, outbursts of intense anger, and seriously impaired role functioning. The severity of the BPD symptom profile, its prevalence, chronicity and high burden upon health care services make the development of effective and accessible treatment for BPD a high priority. Yet there is no current medication treatment indicated for BPD and the psychotherapies recognized for the disorder have been shown to have small effect sizes and are of limited availability.
The present study builds upon work by the study group that has shown that deficiencies in the ability to regulate emotion by engaging typically adaptive cognitive strategies (cognitive reappraisal, CR) and to effectively activate associated neural systems can be corrected by focused training in CR. The R61 phase of this study examines a manualized intensive training program in CR, tests that it effects target neural systems implicated in emotional processing and enhances behavioral reappraisal success. It examines 2-, 4- and 6- weeks of twice a week treatment to identify the optimal dose. Measures include fMRI imaging and clinical ratings at baseline and each of these subsequent time points. Upon demonstrating that CR training is superior to a control condition in enhancing performance in the neural target at one or more of these dose durations, the study team will proceed to the R33 phase. In the R33 phase the study team will treat a larger sample of BPD patients at the optimal dose defined in the R61 phase to 1) demonstrate reproducibility of the R61 findings, 2) to demonstrate that CR training is superior to control in improving BPD clinical outcomes at the end of treatment and at 1- and 4- month follow-up, and 3) that change in activity at the neural targets is associated with clinical improvement.
The results of this study can support the introduction of CR training as a new psychosocial approach for the treatment of BPD, either as stand-alone treatment or as an augmenting strategy. It may, moreover, have application to a range of psychiatric disorders characterized by severe emotional instability.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Cognitive Reappraisal-by-Distancing (CRD) | Experimental | Subjects will be coached to use cognitive reappraisal-by-distancing to downregulate their negative reactions to aversive emotional pictures usng practice pictures. |
|
| Control Downregulate Condition (CD) | Active Comparator | Subjects will be coached to practice their customary emotion regulatory techniques in a treatment occurring twice a week for 6 weeks. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cognitive Reappraisal by Distancing | Behavioral | Reappraisal-by-distancing treatment. Participants meet 2 times a week for 6 weeks to learn reappraisal by distancing through repeated practice with negative emotional pictures. The therapist will help model and shape the technique. . |
| Measure | Description | Time Frame |
|---|---|---|
| Change in PINES Network Activity | BOLD signal change in Picture Induced Negative Emotion Signature (PINES) network activity that includes the amygdala, insula, and other regions by measuring neural activation using fMRI. | Baseline and up to 6 weeks of treatment |
| Change in Zanarini Rating Scale for Borderline Personality (ZAN-BPD) | Zanarini Rating Scale for Borderline Personality, self-report. Full scale from 0-36. Higher score indicates poorer health outcomes. | Baseline and up to 6 weeks of treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Change in ZAN-BPD Sector Scores | There are three affective symptoms in the ZAN-BPD (with a sector score ranging from 0-12): inappropriate anger/frequent angry acts, mood instability, and chronic feelings of emptiness. There are two cognitive symptoms (with a sector score ranging from 0-8): stress-related paranoia/dissociation and severe identity disturbance. (Identity disturbance was placed in the cognitive realm because it is based on a series of false beliefs or overvalued ideas, such as that one is a bad person.) There are also two impulsive symptoms (with a sector score ranging from 0-8): self-mutilative/suicidal efforts and at least two other forms of impulsivity. Finally, there are two symptoms in the interpersonal realm of BPD (with a sector score ranging from 0-8): frantic efforts of avoid abandonment and intense, unstable relationships. The four sector scores sum to provide a total score of borderline psychopathology, which ranges from 0-36. Higher score indicates poorer health outcomes |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Harold Koenigsberg, MD | Icahn School of Medicine at Mount Sinai | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Icahn School of Medicine at Mount Sinai | New York | New York | 10024 | United States |
Individual participant data that underlie the results reported in this article, after deidentification (text, tables, figures, and appendices).
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Beginning 9 months and ending 36 months following article publication.
Investigators whose proposed use of the data has been approved by an independent review committee identified for this purpose. For individual participant data meta-analysis.
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60 participants consented. After preliminary screening visits, 26 participants were randomized.
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| ID | Title | Description |
|---|---|---|
| FG000 | All Participants Consented | All participants consented and had screening visit |
| FG001 | Cognitive Reappraisal-by-Distancing (CRD) | Subjects will be coached to use cognitive reappraisal-by-distancing to downregulate their negative reactions to aversive emotional pictures using practice pictures. Cognitive Reappraisal by Distancing: Reappraisal-by-distancing treatment. Participants meet 2 times a week for 6 weeks to learn reappraisal by distancing through repeated practice with negative emotional pictures. The therapist will help model and shape the technique. |
| FG002 | Control Downregulate Condition (CD) | Subjects will be coached to practice their customary emotion regulatory techniques in a treatment occurring twice a week for 6 weeks. Control Downregulate Condition: Participants either meet 2x a week for 6- weeks to gain added practice, under the guidance of a therapist, using their customary emotion regulatory strategies to downregulate their negative reactions to aversive pictures. |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Screening Visits |
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| Randomized |
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| ID | Title | Description |
|---|---|---|
| BG000 | Cognitive Reappraisal-by-Distancing (CRD) | Subjects will be coached to use cognitive reappraisal-by-distancing to downregulate their negative reactions to aversive emotional pictures using practice pictures. Cognitive Reappraisal by Distancing: Reappraisal-by-distancing treatment. Participants meet 2 times a week for 6 weeks to learn reappraisal by distancing through repeated practice with negative emotional pictures. The therapist will help model and shape the technique. |
| Units | Counts |
|---|---|
| Participants |
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| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Change in PINES Network Activity | BOLD signal change in Picture Induced Negative Emotion Signature (PINES) network activity that includes the amygdala, insula, and other regions by measuring neural activation using fMRI. | Data available for participants who had procedure | Posted | Mean | Standard Deviation | BOLD Signal | Baseline and up to 6 weeks of treatment |
|
6 weeks
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | Cognitive Reappraisal-by-Distancing (CRD) | Subjects will be coached to use cognitive reappraisal-by-distancing to downregulate their negative reactions to aversive emotional pictures using practice pictures. Cognitive Reappraisal by Distancing: Reappraisal-by-distancing treatment. Participants meet 2 times a week for 6 weeks to learn reappraisal by distancing through repeated practice with negative emotional pictures. The therapist will help model and shape the technique. |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| Dr. Harold W Koenigsberg | Icahn School of Medicine at Mount Sinai | (718) 584-9000 | harold.koenigsberg@mssm.edu |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Feb 12, 2025 | Apr 18, 2025 | Prot_SAP_000.pdf |
| ICF | No | No | Yes | Informed Consent Form | Feb 12, 2025 | Apr 18, 2025 | ICF_001.pdf |
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| ID | Term |
|---|---|
| D001883 | Borderline Personality Disorder |
| ID | Term |
|---|---|
| D010554 | Personality Disorders |
| D001523 | Mental Disorders |
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|
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| Control Downregulate Condition | Behavioral | Participants either meet 2x a week for 6- weeks to gain added practice, under the guidance of a therapist, using their customary emotion regulatory strategies to downregulate their negative reactions to aversive pictures. |
|
|
| Baseline and at 2-,4-, and 6-weeks |
| Change in Affective Lability Scale Total (ALS) | The Affective Lability Scale (ALS) consists of 54 items which are rated on a four-point Likert scale ranging from 0 ("very uncharacteristic of me") to 3 ("very characteristic of me"). Five of the items refer to shifts in anxiety/depression, eight refer to shifts in depression/elation, and the final five items concern shifts between anger and normal mood. The scale yields a total score of ALS, as well as subscores for the three affective domains. Total score range from 0 to 162, with higher score indicating more affective lability. | Baseline and at 2-,4-, and 6-weeks |
| Change in Perceived Stress Scale (PSS) | Perceive Stress Scale (PSS) - A 10-item questionnaire, each item scored 0 (never) to 4 (very often), full scale from 0-40, with higher score indicating higher perceived stress or the more often the person perceives stress. | Baseline and at 2-,4-, and 6-weeks |
| Change in Difficulty in Emotion Regulation Scale Scores (DERS) | Difficulties in emotion regulation scale (DERS) The DERS is a 36-item self-report measure of six facets of emotion regulation. Items are rated on a scale of 1 (" almost never [0-10%] ") to 5 (" almost always [91-100%] "). Total scale from 6-216. Higher scores indicate more difficulty in emotion regulation. | Baseline and at 2-,4-, and 6-weeks |
| Change in Beck Depression Scale Score (BDI) | The Beck Depression Inventory (BDI) is used to evaluate depression symptoms. This questionnaire is a 21-item, self-report rating inventory that measures characteristic attitudes and symptoms of depression. Scoring is from 0 (minimal) to 3 (severe), with total score from 0-63. Higher total scores indicate more severe depressive symptoms. | Baseline and at 2-,4-, and 6-weeks |
| Change in State-Trait Anxiety Scale Score (STAXI) | A 40 self-report items questionnaire, each item scored on 4-point likert-type response scale from 1 (not at all) to 4 (almost always), full range from 40 to 160, with higher score suggesting higher levels of anxiety.4 | Baseline and at 2-,4-, and 6-weeks |
| NOT COMPLETED |
|
|
| BG001 | Control Downregulate Condition (CD) | Subjects will be coached to practice their customary emotion regulatory techniques in a treatment occurring twice a week for 6 weeks. Control Downregulate Condition: Participants either meet 2x a week for 6- weeks to gain added practice, under the guidance of a therapist, using their customary emotion regulatory strategies to downregulate their negative reactions to aversive pictures. |
| BG002 | Total | Total of all reporting groups |
| years |
|
| Sex: Female, Male | Count of Participants | Participants |
|
| Ethnicity (NIH/OMB) | Count of Participants | Participants |
|
| Race (NIH/OMB) | Count of Participants | Participants |
|
| OG001 | Control Downregulate Condition (CD) | Subjects will be coached to practice their customary emotion regulatory techniques in a treatment occurring twice a week for 6 weeks. Control Downregulate Condition: Participants either meet 2x a week for 6- weeks to gain added practice, under the guidance of a therapist, using their customary emotion regulatory strategies to downregulate their negative reactions to aversive pictures. |
|
|
| Primary | Change in Zanarini Rating Scale for Borderline Personality (ZAN-BPD) | Zanarini Rating Scale for Borderline Personality, self-report. Full scale from 0-36. Higher score indicates poorer health outcomes. | Data available for participants who completed instrument. | Posted | Mean | Standard Deviation | score on a scale | Baseline and up to 6 weeks of treatment |
|
|
|
| Secondary | Change in ZAN-BPD Sector Scores | There are three affective symptoms in the ZAN-BPD (with a sector score ranging from 0-12): inappropriate anger/frequent angry acts, mood instability, and chronic feelings of emptiness. There are two cognitive symptoms (with a sector score ranging from 0-8): stress-related paranoia/dissociation and severe identity disturbance. (Identity disturbance was placed in the cognitive realm because it is based on a series of false beliefs or overvalued ideas, such as that one is a bad person.) There are also two impulsive symptoms (with a sector score ranging from 0-8): self-mutilative/suicidal efforts and at least two other forms of impulsivity. Finally, there are two symptoms in the interpersonal realm of BPD (with a sector score ranging from 0-8): frantic efforts of avoid abandonment and intense, unstable relationships. The four sector scores sum to provide a total score of borderline psychopathology, which ranges from 0-36. Higher score indicates poorer health outcomes | Data available for participants who completed instrument. | Posted | Mean | Standard Deviation | score on a scale | Baseline and at 2-,4-, and 6-weeks |
|
|
|
| Secondary | Change in Affective Lability Scale Total (ALS) | The Affective Lability Scale (ALS) consists of 54 items which are rated on a four-point Likert scale ranging from 0 ("very uncharacteristic of me") to 3 ("very characteristic of me"). Five of the items refer to shifts in anxiety/depression, eight refer to shifts in depression/elation, and the final five items concern shifts between anger and normal mood. The scale yields a total score of ALS, as well as subscores for the three affective domains. Total score range from 0 to 162, with higher score indicating more affective lability. | Data available for participants who completed instrument. | Posted | Mean | Standard Deviation | score on a scale | Baseline and at 2-,4-, and 6-weeks |
|
|
|
| Secondary | Change in Perceived Stress Scale (PSS) | Perceive Stress Scale (PSS) - A 10-item questionnaire, each item scored 0 (never) to 4 (very often), full scale from 0-40, with higher score indicating higher perceived stress or the more often the person perceives stress. | Data available for participants who completed instrument. | Posted | Mean | Standard Deviation | score on a scale | Baseline and at 2-,4-, and 6-weeks |
|
|
|
| Secondary | Change in Difficulty in Emotion Regulation Scale Scores (DERS) | Difficulties in emotion regulation scale (DERS) The DERS is a 36-item self-report measure of six facets of emotion regulation. Items are rated on a scale of 1 (" almost never [0-10%] ") to 5 (" almost always [91-100%] "). Total scale from 6-216. Higher scores indicate more difficulty in emotion regulation. | Results available for participants who completed instrument | Posted | Mean | Standard Deviation | score on a scale | Baseline and at 2-,4-, and 6-weeks |
|
|
|
| Secondary | Change in Beck Depression Scale Score (BDI) | The Beck Depression Inventory (BDI) is used to evaluate depression symptoms. This questionnaire is a 21-item, self-report rating inventory that measures characteristic attitudes and symptoms of depression. Scoring is from 0 (minimal) to 3 (severe), with total score from 0-63. Higher total scores indicate more severe depressive symptoms. | Data for participants who completed instrument | Posted | Mean | Standard Deviation | score on a scale | Baseline and at 2-,4-, and 6-weeks |
|
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|
| Secondary | Change in State-Trait Anxiety Scale Score (STAXI) | A 40 self-report items questionnaire, each item scored on 4-point likert-type response scale from 1 (not at all) to 4 (almost always), full range from 40 to 160, with higher score suggesting higher levels of anxiety.4 | Data for participants who completed instrument. | Posted | Mean | Standard Deviation | score on a scale | Baseline and at 2-,4-, and 6-weeks |
|
|
|
| 0 |
| 13 |
| 0 |
| 13 |
| 0 |
| 13 |
| EG001 | Control Downregulate Condition (CD) | Subjects will be coached to practice their customary emotion regulatory techniques in a treatment occurring twice a week for 6 weeks. Control Downregulate Condition: Participants either meet 2x a week for 6- weeks to gain added practice, under the guidance of a therapist, using their customary emotion regulatory strategies to downregulate their negative reactions to aversive pictures. | 0 | 13 | 0 | 13 | 0 | 13 |
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| after up to 6 weeks of treatment |
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| Baseline - Cognitive Sector |
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| Baseline - Impulsive Sector |
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| Baseline - Interpersonal Sector |
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| 2 weeks - Affective Sector |
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| 2 weeks - Cognitive Sector |
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| 2 weeks - Impulsive Sector |
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| 2 weeks- Interpersonal Sector |
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| 4 weeks - Affective Sector |
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| 4 weeks - Cognitive Sector |
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| 4 weeks - Impulsive Sector |
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| 4 weeks - Interpersonal Sector |
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| 6 weeks - Affective Sector |
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| 6 weeks - Cognitive Sector |
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| 6 weeks - Impulsive Sector |
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| 6 weeks - Interpersonal Sector |
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| 2 weeks |
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| 4 weeks |
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| 6 weeks |
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| 2 weeks |
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| 4 weeks |
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| 6 weeks |
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| 2 weeks |
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| 4 weeks |
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| 6 weeks |
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| 2 weeks |
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| 4 weeks |
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| 6 weeks |
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| 2 weeks |
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| 4 weeks |
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| 6 weeks |
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