Calcinosis Reduction by Pyrophosphate in SSC

The Effect of Orally Administered Pyrophosphate on Calcinosis Formation in Systematic Sclerosis

Calcinosis, i.e. crystal-like nodules are troublesome complication of systemic sclerosis, an autoimmune disease. Pyrophosphate inhibits its formation is laborytory. We would like to test if orally administered pyrophosphate prevents calcinosis formation.

Calcinosis, the formation of hydroxyapatite subcutaneous nodules, often complicates systemic sclerosis. There is no standard treatment for it. Based upon our preclinical experienc, we would like to test it orally administered pyrophosphate inhibits calciosis.

Inclusion Criteria:

• to meet ACR/ EULAR classification criteria

Exclusion Criteria:

• severe upper minfestation of SSC
• hypo- or hyperthyreoidism
• QT prolongation on ECG