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We aim to examine, whether hospitalization is associated with higher high-sensitivity cardiac troponin T (hs-cTnT) serum concentrations in patients without a cardiac disease.
High-sensitivity cardiac troponin T (hs-cTnT) values will be obtained in hospitalized patients a) without a diagnosed or suspected cardiac disease, and b) with an acute medical condition that is not commonly associated with an increase of hs-cTnT concentrations. As a reference, a second sampling of blood for an analysis of the hs-cTnT serum concentration will be obtained in the same patients after discharge (60 days after hospitalization).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with low disease severity | Hospitalized patients without a diagnosed or suspected cardiac disease and with an acute medical condition of low severity (e.g. patients with retinal detachment) |
| |
| Patients with medium disease severity | Hospitalized patients without a diagnosed or suspected cardiac disease and with an acute medical condition of medium severity (e.g. patients with an uncomplicated acute pancreatitis oder an acute exacerbation of a chronic inflammatory bowel disease) |
| |
| Patients with high disease severity | Hospitalized patients without a diagnosed or suspected cardiac disease and with an acute medical condition of high severity (e.g. patients with a proximal femoral fracture) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Analysis of hs-cTnT serum concentration at hospitalization | Diagnostic Test | Analysis of the hs-cTnT serum concentration in the blood drawn at the day of hospitalization |
|
| Measure | Description | Time Frame |
|---|---|---|
| Difference of the hs-cTnT concentration at hospitalization and after discharge | 60 days |
| Measure | Description | Time Frame |
|---|---|---|
| Difference of the hs-cTnT concentration at hospitalization and after discharge in acute medical conditions of low severity | 60 days | |
| Difference of the hs-cTnT concentration at hospitalization and after discharge in acute medical conditions of medium severity |
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Inclusion Criteria:
Exclusion Criteria:
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312 patients with an acute, non-cardiac medical condition of low, medium or high severity (104 patients per group)
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Leipzig Medical Center | Leipzig | 04103 | Germany |
Available upon reasonable scientific request
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| Analysis of hs-cTnT serum concentration after discharge | Diagnostic Test | Analysis of the hs-cTnT serum concentration in the blood drawn after discharge (60 days after hospitalization) |
|
| 60 days |
| Difference of the hs-cTnT concentration at hospitalization and after discharge in acute medical conditions of high severity | 60 days |
| Prediction of 1-year-mortality by hs-cTnT concentration | 1 year |
| Prediction of 1-year-hospitalization rate due to a cardiovascular disease by hs-cTnT concentration | 1 year |