Thrombin Generation in Beta-thalassemia Major

Evaluation of Hypercoagulability by Thrombin Generation Test in Beta-thalassemia Major

This study aims to evaluate the persistence of a hypercoagulable state in chronically-transfused patients with beta thalassemia major, by using the thrombin generation test (performed in whole blood and plasma). Patients will be compared with 2 control groups: 1/ healthy volunteers and 2/ carriers of beta-thalassemia trait

Inclusion Criteria:

• Patient with de Beta-thalassemia major
• Patient with regular blood transfusion regimen (every 4 - 6 weeks)
• informed and signed consent
• weight > 30kg
• Hemoglobin > 7g/dL

Exclusion Criteria:

• Emergency situation
• Patients receiving antithrombotic drugs (anticoagulants such as Vitamin K antagonism, heparin or direct oral anticoagulant) or antiplatelet drugs;
• women of childbearing age without contraception
• pregnancy
• deprivation of liberty
• no consent