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| Name | Class |
|---|---|
| L-Nutra Inc | INDUSTRY |
| Peak Human Labs | UNKNOWN |
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This is a prospective randomized clinical study of 50 patients to evaluate the fasting mimicking diet program by Prolon with a calorie mimetic supplement from Peak Human Labs. This study will be evaluating the effectiveness of the combined intervention over a three month program.
The study will assess the effects that the program has on the participants' biological aging.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Fasting Mimicking Diet + Supplement / Usual Routine | Experimental | Participants in will be asked to begin the Peak Human Labs calorie mimetic supplement. They will also begin on day 1 the 5 day Fasting Mimicking Diet Program. Participants will continue the supplementation for the 90 days and repeat the 5 day Fasting Mimicking Diet Program on days 1, 29 and 57. Starting at day 91, they will return to their usual daily routine. |
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| Supplement / Usual Routine | Experimental | Participants will be asked to begin the Peak Human Labs calorie mimetic supplement. Participants will continue the supplementation for 90 days. Starting at day 91, they will return to their usual daily routine. |
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| Usual Routine / Fasting Mimicking Diet + Supplement | Experimental | Participants will have no intervention for the first 90 days, during which they will be asked not to start a new fasting program supplement. At day 91, they will begin the 5-day Fasting Mimicking Diet Program and start the Peak Human Labs calorie mimetic supplement. Participants will continue the supplementation for 90 days and repeat the 5-day Fasting Mimicking Diet Program on days 91, 120, and 148. |
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| Usual Routine / Supplement | Experimental | Participants will have no intervention for the first 90 days, during which they will be asked not to start a new fasting program supplement. At day 91,start the Peak Human Labs calorie mimetic supplement. Participants will continue the supplementation for 90 days. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Peak Human Labs calorie mimetic supplement | Dietary Supplement | Supplement |
|
| Measure | Description | Time Frame |
|---|---|---|
| Epigenetic Age Biomarkers | Outcome epigenetic age testing will test methylation at 850,000 spots on the DNA/ | Change from baseline to 3 months |
| Epigenetic Age Biomarkers | Outcome epigenetic age testing will test methylation at 850,000 spots on the DNA/ | Change from baseline to 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Body Mass Index | Change from baseline to 6 months |
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Inclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Peak Human Labs | Brampton | Ontario | L6W 3E1 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30930169 | Background | Amano H, Chaudhury A, Rodriguez-Aguayo C, Lu L, Akhanov V, Catic A, Popov YV, Verdin E, Johnson H, Stossi F, Sinclair DA, Nakamaru-Ogiso E, Lopez-Berestein G, Chang JT, Neilson JR, Meeker A, Finegold M, Baur JA, Sahin E. Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease. Cell Metab. 2019 Jun 4;29(6):1274-1290.e9. doi: 10.1016/j.cmet.2019.03.001. Epub 2019 Mar 28. | |
| 26094889 |
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prospective, randomized trial
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| Fasting Mimicking Diet | Behavioral | Diet |
|
| Background |
| Brandhorst S, Choi IY, Wei M, Cheng CW, Sedrakyan S, Navarrete G, Dubeau L, Yap LP, Park R, Vinciguerra M, Di Biase S, Mirzaei H, Mirisola MG, Childress P, Ji L, Groshen S, Penna F, Odetti P, Perin L, Conti PS, Ikeno Y, Kennedy BK, Cohen P, Morgan TE, Dorff TB, Longo VD. A Periodic Diet that Mimics Fasting Promotes Multi-System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metab. 2015 Jul 7;22(1):86-99. doi: 10.1016/j.cmet.2015.05.012. Epub 2015 Jun 18. |
| 28343910 | Background | Chen J, Li Y, Zhu Q, Li T, Lu H, Wei N, Huang Y, Shi R, Ma X, Wang X, Sheng J. Anti-skin-aging effect of epigallocatechin gallate by regulating epidermal growth factor receptor pathway on aging mouse model induced by d-Galactose. Mech Ageing Dev. 2017 Jun;164:1-7. doi: 10.1016/j.mad.2017.03.007. Epub 2017 Mar 24. |