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This study investigates the potential of cranial electrotherapy stimulation to mitigate anxiety induced cognitive deficits
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental - Induced Anxiety | Experimental | Participants will be administered a shock procedure in which they are exposed to safe electrical shock that will be gradually increase from (1) 30 milliseconds to (4) 80 milliseconds to an individual threshold that is uncomfortable but not painful. Participants will be told they may receive additional shocks for poor performance during cognitive assessments. Participants will be administered cranial electrotherapy stimulation with a frequency of .5 Hz and a current of 100 microamps during 30 minutes of cognitive assessments of task switching, inhibition (stroop), working memory (n-back), and processing speed (simple reaction time). |
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| Experimental - No Induced Anxiety | Experimental | Participants will be administered a shock procedure in which they are exposed to safe electrical shock that will be gradually increase from (1) 30 milliseconds to (4) 80 milliseconds to an individual threshold that is uncomfortable but not painful. After this procedure, the shock belt will be turned off. Participants will be told they will not receive additional shocks during cognitive assessments. Participants will be administered cranial electrotherapy stimulation with a frequency of .5 Hz and a current of 100 microamps during 30 minutes of cognitive assessments of task switching, inhibition (stroop), working memory (n-back), and processing speed (simple reaction time). |
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| Sham - Induced Anxiety | Sham Comparator | Participants will be administered a shock procedure in which they are exposed to safe electrical shock that will be gradually increase from (1) 30 milliseconds to (4) 80 milliseconds to an individual threshold that is uncomfortable but not painful. Participants will be told they may receive additional shocks for poor performance during cognitive assessments. Participants will be administered sham cranial electrotherapy stimulation with no current during 30 minutes of cognitive assessments of task switching, inhibition (stroop), working memory (n-back), and processing speed (simple reaction time). |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cranial Electrotherapy Stimulation | Device | Participants will receive cranial electrotherapy stimulation stimulation on one of two separate visits (within-subjects). |
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| Measure | Description | Time Frame |
|---|---|---|
| Task switching | Switch cost (mean switch reaction time- mean stay reaction time) | 68 weeks |
| Working memory (N-back) | 2-back condition mean accuracy | 68 weeks |
| Inhibition (Stroop) | Stroop interference cost (mean incongruent reaction time- mean congruent reaction time) | 68 weeks |
| Processing speed (Simple reaction time task) | Mean reaction time | 68 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tufts University | Medford | Massachusetts | 02155 | United States |
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| ID | Term |
|---|---|
| D001008 | Anxiety Disorders |
| D003072 | Cognition Disorders |
| ID | Term |
|---|---|
| D001523 | Mental Disorders |
| D019965 | Neurocognitive Disorders |
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All study staff are blinded to active and sham brain stimulation devices until the completion of data collection.
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| Sham - No Induced Anxiety | Sham Comparator | Participants will be administered a shock procedure in which they are exposed to safe electrical shock that will be gradually increase from (1) 30 milliseconds to (4) 80 milliseconds to an individual threshold that is uncomfortable but not painful. After this procedure, the shock belt will be turned off. Participants will be told they will not receive additional shocks during cognitive assessments. Participants will be administered sham cranial electrotherapy stimulation with no current during 30 minutes of cognitive assessments of task switching, inhibition (stroop), working memory (n-back), and processing speed (simple reaction time). |
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| Sham Cranial Electrotherapy Stimulation | Device | Participants will receive sham stimulation on one of two separate visits (within-subjects). |
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