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To explore the HRCT phenotype of the combined COPD assessment staging system
HRCT can be rapidly and safely deployed has enabled COPD research to move beyond FEV1 by facilitating and amplifying clinical phenotyping measurements, providing quantitative information, and detecting significant responses to therapy even in the absence of significant FEV1 improvements.
We explore the HRCT phenotype of the combined COPD assessment staging system,and found that:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A in GOLD | CAT<10、mMRC 0-1、FEV1%≥50%、the frequency of acute exacerbations in the past year<2; | ||
| Group B in GOLD | CAT≥10、mMRC≥2、FEV1%≥50%、the frequency of acute exacerbations in the past year<2 | ||
| Group C in GOLD | CAT<10、mMRC 0-1、 FEV1%<50%、the frequency of acute exacerbations in the past year≥2 or leading to hospital admission≥1 | ||
| Group D in GOLD | CAT≥10、mMRC≥2、FEV1%<50%、the frequency of acute exacerbations in the past year≥2 or leading to hospital admission≥1 | ||
| Control Group | not COPD |
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| Measure | Description | Time Frame |
|---|---|---|
| The severity of emphysema | % low attenuation area <950 HU (LAA %) | Within an average of 3 days after diagnosis of COPD |
| Indicator A of the severity of airway stenosis | The inner diameter of bronchial (LD) in centimeter | Within an average of 3 days after diagnosis of COPD |
| Indicator B of the severity of airway stenosis | The bronchial wall thickness in centimeter | Within an average of 3 days after diagnosis of COPD |
| Indicator C of the severity of airway stenosis | Ratio of thickness and outer diameter (TDR) | Within an average of 3 days after diagnosis of COPD |
| Indicator D of the severity of airway stenosis | % wall area for bronchial external diameter (WA%) | Within an average of 3 days after diagnosis of COPD |
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Inclusion Criteria:
Exclusion Criteria:
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consecutive outpatients
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Peking University Third Hospital | Beijing | 100080 | China |
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| ID | Term |
|---|---|
| D029424 | Pulmonary Disease, Chronic Obstructive |
| D008171 | Lung Diseases |
| ID | Term |
|---|---|
| D008173 | Lung Diseases, Obstructive |
| D012140 | Respiratory Tract Diseases |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
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| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |