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The purpose of this experiment is to compared the changes of thyroid function, anti-thyroid peroxidase antibody, anti-thyroglobulin antibody, thyroid magnetic resonance T1-mapping and various metabolic indexes from baseline to the end of treatment (after the thyroid function had been normal for more than three months)
In patients with autoimmune thyroiditis with mild subclinical hypothyroidism, the study period will include a screening period of not more than 30 days, and a 12-week treatment period compared to baseline. At completion of treatment, Thyroid Stimulating Hormone(TSH), free thyroxine (FT4)，free thyroxine (FT3) will be included. The changes of anti-thyroglobulin antibody, anti-thyroglobulin antibody, T1-mapping and metabolic indexes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| levothyroxine sodium | Experimental | levothyroxine sodium |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Levothyroxine Sodium Tablets | Drug | Levothyroxine Sodium(50ug/Tablets,dosage form 25ug,once a day) was administered to patients with autoimmune thyroiditis with mild subclinical hypothyroidism, |
| Measure | Description | Time Frame |
|---|---|---|
| Thyroid Stimulating Hormone changes | Thyroid Stimulating Hormone Changes from baseline and 12 weeks during follow-up | Thyroid Stimulating Hormone Changes from baseline and 12 weeks during follow-up |
| free thyroxine changes | free thyroxine changes from baseline and 12 weeks during follow-up | free thyroxine changes from baseline and 12 weeks during follow-up |
| T1-mapping values of Thyroid MRI | T1-mapping values of Thyroid MRI Changes from baseline and 12 weeks during follow-up | T1-mapping values of Thyroid MRI Changes from baseline and 12 weeks during follow-up |
| Free triiodothyronine changes | Free triiodothyronine changes Changes from baseline and 12 weeks during follow-up | Free triiodothyronine changes Changes from baseline and 12 weeks during follow-up |
| Measure | Description | Time Frame |
|---|---|---|
| anti-thyroid peroxidase antibody changes | anti-thyroid peroxidase antibody changes from baseline and 12 weeks during follow-up | anti-thyroid peroxidase antibody changes from baseline and 12 weeks during follow-up |
| anti-thyroglobulin antibody changes |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jia Liu, MD | Contact | 861085231710 | liujia0116@126.com | |
| Xiaomeng Sun, MD | Contact | 861085231711 | beijingxiaosun2010@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Guang Wang, MD | Beijing Chao-Yang Hospital, Capital Medical University, Beijing | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing Chao-Yang Hospital, Capital Medical University | Recruiting | Beijing | Beijing Municipality | China |
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| ID | Term |
|---|---|
| D013974 | Thyroxine |
| ID | Term |
|---|---|
| D013963 | Thyroid Hormones |
| D006728 | Hormones |
| D006730 | Hormones, Hormone Substitutes, and Hormone Antagonists |
| D024322 | Amino Acids, Aromatic |
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anti-thyroglobulin antibody changes from baseline and 12 weeks during follow-up
| anti-thyroglobulin antibody changes from baseline and 12 weeks during follow-up |
| D000598 | Amino Acids, Cyclic |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |