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This study intends to make full use of the advantage of spinal orthopedic surgery in our medical center.Analyze the blood loss and blood coagulation function and the influence of safety of load dose tranexamic acid (TXA) in scoliosis surgery during perioperative.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normal saline（I） | Intravenous infusion of 0.9% saline when start to cut the skin，do not intravenous tranexamic acid during the surgery | ||
| Tranexamic acid（II） | Intravenous infusion of tranexamic acid 1g when start to cut the skin in 1 hour |
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| Measure | Description | Time Frame |
|---|---|---|
| Intraoperative blood loss | Intraoperative blood loss | At the end of the surgery |
| Incision drainage Incision drainage Incision drainage after surgery | Incision drainage after surgery | 24 hours after surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Autologous blood doping | Recycle the blood during the intraoperative , back to the patient | At the end of the surgery |
| red blood cell transfusion | red blood cell transfusion |
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Inclusion Criteria:
Exclusion Criteria:
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age:18-60 years old；American Society of Anesthesiologists (ASA):I-II；The spinal orthopedic undergoing elective surgery
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| At the end of the surgery |
| Plasma infusion | Plasma infusion | At the end of the surgery |
| HB | hemoglobin | Within 1 week before surgery；1 day after surgery |
| WBC | White blood cells | Within 1 week before surgery；1 day after surgery |
| PTL | platelet | Within 1 week before surgery；1 day after surgery |
| PT | Prothrombin time | Within 1 week before surgery；1 day after surgery |
| APTT | activated partial thromboplastin time | Within 1 week before surgery；1 day after surgery |
| INR | International Normalized Ratio | Within 1 week before surgery；1 day after surgery |