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The patients suffered from acute lung ininjury (200\
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| hUC-MSCs treatment | Placebo Comparator | Patients of acute lung injury will be treated by suspention of hUC-MSCs and albumin combined with standard therapies. |
|
| non-cell therapy | No Intervention | Patients of acute lung injury will be treated by vehicle (albumin) combined with standard therapies. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| human derived umbilical cord derived mesenchymal stem cells | Biological | intravenous transplantation of human derived umbilical cord derived mesenchymal stem cells |
|
| Measure | Description | Time Frame |
|---|---|---|
| PaO2/FiO2 | Oxygenation index | Day 3 |
| PaO2/FiO2 | Oxygenation index | Day 7 |
| PaO2/FiO2 | Oxygenation index | Day 14 |
| PaO2/FiO2 | Oxygenation index | Day 28 |
| Measure | Description | Time Frame |
|---|---|---|
| the days of ventialtion and hospital stay | the length of ventilation and hospital stay | Day 3 |
| the days of ventialtion and hospital stay | the length of ventilation and hospital stay |
| Measure | Description | Time Frame |
|---|---|---|
| IL-6 | inflammatory factors | Day 1 |
| IL-6 | inflammatory factors | Day 7 |
Inclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| SAHZU | Recruiting | Hanzhou | Zhejiang | 310009 | China |
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| ID | Term |
|---|---|
| D055371 | Acute Lung Injury |
| ID | Term |
|---|---|
| D055370 | Lung Injury |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
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| Day 7 |
| the days of ventialtion and hospital stay | the length of ventilation and hospital stay | Day 14 |
| the days of ventialtion and hospital stay | the length of ventilation and hospital stay | Day 28 |
| IL-6 |
inflammatory factors |
| Day 14 |
| IL-6 | inflammatory factors | Day 28 |
| IL-8 | inflammatory factors | Day 1 |
| IL-8 | inflammatory factors | Day 7 |
| IL-8 | inflammatory factors | Day 14 |
| IL-8 | inflammatory factors | Day 28 |
| TNF-a | inflammatory factors | Day 3 |
| TNF-a | inflammatory factors | Day 7 |
| TNF-a | inflammatory factors | Day 14 |
| TNF-a | inflammatory factors | Day 28 |