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The purpose of this study is to test the reliability and validity of an artificial intelligence system and a related 5-score scale to predict hematoma expansion, and conduct a study cohort of intracerebral hemorrhage to screen out imaging and biological markers that could predict hematoma expansion in real-world.
This is a investigator-initiated, multi-center, prospective, registered cohort study. The study is intended to enroll 4000 patients with intracerebral hemorrhage from 50 hospital in China. Clinical and imaging data, as well as the results of laboratory examination will be collected to test the reliability and validity of an artificial intelligence system and a related 5-score scale to predict hematoma expansion, and conduct a study cohort of intracerebral hemorrhage to screen out imaging and biological markers that could predict hematoma expansion in real-world.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Hematoma Expansion (HE) group | |||
| non-HE group |
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| Measure | Description | Time Frame |
|---|---|---|
| hematoma expansion | non-contrast CT scan: the enlargement of hematoma ≥6ml | 24-48 hours from symptom onset |
| Recurrence of intracerebral hemorrhage | non-contrast CT scan: non-traumatic intracerebral hemorrhage other than the primary hemotoma | 90 days from symptom onset |
| Functional dependence | modified Rankin Scale score ≥3 (a global measure of disability on a seven-level scale, with scores ranging from 0 (no symptoms) to 6 (death), higher scores mean a better or worse outcome ) | 3 months |
| Cerebrovascular death | Death due to one of the following events: ischemic stroke or hemorrhagic stroke | 3 months |
| Cardiovascular death | Death due to one of the following events: sudden cardiac death or acute myocardial infarction or heart failure | 3 months |
| Measure | Description | Time Frame |
|---|---|---|
| New ischemic stroke | Acute focal neurological impairment corresponding with infarction on CT/MR scan | 3 months |
| New subarachnoid hemorrhage | Hemorrhage in subarachnoid space proven on CT/MR scan |
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Inclusion Criteria:
Exclusion Criteria:
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Patients diagnosed with sICH that arrived at hospital within 24 hours.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Beijing Tiantan Hospital | Beijing | China |
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| ID | Term |
|---|---|
| D002543 | Cerebral Hemorrhage |
| ID | Term |
|---|---|
| D020300 | Intracranial Hemorrhages |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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blood samples and urine samples
| 3 months |
| Other cardiovascular events | One of the following events: non-fatal myocardial infarction or non-fatal heart failure | 3 months |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D006470 | Hemorrhage |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |