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People with dementia shows a decline in cognition, such as memory, executive function (EF), language, attention, and spatial orientation that is significant enough to interfere with the independence and daily functioning. Previous studies reported that multicomponent exercise improved EF in people with mild cognitive impairment and independence of ADL in those with Alzheimer's disease. However, few studies investigated whether multicomponent exercise improved EF, memory, and ADL in people with dementia. Therefore, the purposes of this study are to examine 1) the effect of multicomponent exercise on EF, memory, and ADL in people with mild to moderate dementia; 2) the correlation between change in EF and ADL; 3) the correlation between change in memory and ADL.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Multicomponent exercise group | Experimental |
| |
| Video home exercise group | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Multicomponent exercise | Other | The intervention is a 60-minute session, 3 times/week, totaling 9 weeks. Multicomponent exercise included strengthening, balance training, aerobic dance, and stretching |
| Measure | Description | Time Frame |
|---|---|---|
| Mini-Mental State Examination | It is a 30-point questionnaire that is used extensively in clinical and research settings to measure cognitive impairment. Higher scores mean a better outcome. | Change from baseline at 9 week |
| Chinese version of Verbal learning test | It is a 9-point measurement to evaluate memory. Higher scores mean a better outcome. | Change from baseline at 9 week |
| Chinese version of Stroop color and word test | It is a measurement to evaluate inhibition control. | Change from baseline at 9 week |
| Digit span test | It is a measurement to evaluate working memory. | Change from baseline at 9 week |
| Trail making test - Chinese version | It is a measurement to evaluate cognitive flexibility. | Change from baseline at 9 week |
| Measure | Description | Time Frame |
|---|---|---|
| Barthel index | It is a 100-point ordinal scale used to measure performance in activities of daily living. Higher scores mean a better outcome. | Change from baseline at 9 week |
| Instrumental activities of daily living (IADL) scale |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Yea-Ru Yang, Professor | Contact | +886-2-28267279 | yryang@nycu.edu.tw |
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| ID | Term |
|---|---|
| D003704 | Dementia |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D019965 | Neurocognitive Disorders |
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| Video home exercise group | Other | The intervention is a 60-minute session, 3 times/week, totaling 9 weeks. Video home exercise included four limbs mobility exercise, stretching, strengthening, and aerobic exercise |
|
It is a 24-point ordinal scale used to measure performance in instrumental activities of daily living. Higher scores mean a better outcome.
| Change from baseline at 9 week |
| Chinese version of Quality of Life in Alzheimer Disease Scale | It is a measurement to evaluate quality of life. The scale scores range from 13 to 52, with higher scores indicating greater quality of life. | Change from baseline at 9 week |
| Time up and go test | It is a test to evaluate functional mobility. | Change from baseline at 9 week |
| 30-second chair stand test | It is a test to evaluate muscle strength. | Change from baseline at 9 week |
| 6-minute walk test | It is a test to evaluate endurance. | Change from baseline at 9 week |
| Berg Balance Scale | It is a tool to evaluate balance. It is a 14 item list with each item consisting of a five-point ordinal scale ranging from 0 to 4, with 0 indicating the lowest level of function and 4 the highest level of function. | Change from baseline at 9 week |
| D001523 | Mental Disorders |