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The aim of the study is to determine the prevalence of anal high-risk HPV infection and abnormal cytology in HIV uninfected Men who have sex with men (MSM) using PrEP and HIV infected MSM followed-up at the S-kliniek or HRC of the UZ Brussel. 200 participants will be preferably included in the study. The data will be collected using a self-administered questionnaire where socio-demographic characteristics, health-related issues and sexual behavior will be questioned. Also anal canal sampling will be performed for cytological analysis. For the HIV infected MSM, additional information will be extracted from the patient files: CD4+ T-cell count and nadir and duration of combination antiretroviral therapy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| HAS-N | Active Comparator | In this arm the patient without HIV using PrEP will be included |
|
| HAS-P | Active Comparator | In this arm the patient with HIV will be included |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| anal sampling | Other | anal sampling will be performed both in men without HIV and men having HIV in order to see if they have HPV or not |
|
| Measure | Description | Time Frame |
|---|---|---|
| To determine the prevalence of anal high risk HPV infection in MSM using PrEP | 2 year |
| Measure | Description | Time Frame |
|---|---|---|
| To compare the prevalence of high risk HPV in MSM using PrEP with that of HIV uninfected MSM not using PrEP | comparation will be done with partially using literature | 2 year |
| To compare the prevalence of high risk HPV in MSM using PrEP with that of HIV infected MSM |
| Measure | Description | Time Frame |
|---|---|---|
| to determine the correlation between abnormal cytology and HPV infection in MSM using PrEP | 2 year | |
| To determine possible correlations between the characteristics asked in the questionnaire and the prevalence of high risk HPV infection in both MSM using PrEP and MSM who have HIV |
Inclusion Criteria:
Exclusion Criteria for MSM using PrEP:
Exclusion Criteria for MSM infected with HPV:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universitair ziekenhuis Brussel | Brussels | 1090 | Belgium |
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| 2 year |
| to determine the prevalence of abnormal anal cytology in MSM using PrEP and in HIV infected MSM | 2 year |
| 2 year |