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The purpose of this study is to compare the efficacy of intra-articular corticosteroid injections versus platelet-rich plasma injections for non-operative treatment of primary glenohumeral osteoarthritis. The efficacy of intra-articular injections, outside of hyaluronic acid, for the treatment of glenohumeral OA is not known, yet these treatments are commonly used with hopes of providing patients with symptomatic relief that can hopefully delay or prevent the need for shoulder arthroplasty. This study will help elucidate the therapeutic benefit of corticosteroid and Platelet Rich Plasma (PRP) injections in this patient population.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Corticosteroid Injection Group | Experimental | 80mg Depo-Medrol and 8cc Lidocaine ultrasound-guided intra-articular injection |
|
| Platelet-Rich Plasma Injection Group | Active Comparator | 15cc blood draw in Arthrex Autologous Conditioned Plasma (ACP) kit and processed per manufacturer instructions Ultrasound-guided intra-articular injection of isolated PRP |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Glenohumeral Injection | Procedure | Patients who enroll will be randomized into an injection group, and then will undergo the specified injection at one time point only. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Visual Analog Scale-Pain (VAS) | Validated patient-reported metric scale of pain: no pain (0-4 mm), mild pain(5-44 mm), moderate pain (45-74 mm), and severe pain (75-100 mm) | 12 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Carla M Edwards, PhD | Contact | 312.563.5735 | carla_edwards@rush.edu |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rush University Medical Center | Recruiting | Chicago | Illinois | 60612 | United States |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| ICF | No | No | Yes | Informed Consent Form | Jul 30, 2020 | Dec 11, 2020 | ICF_000.pdf |
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Double-blinded, randomized