Efficacy of NIV Masks in COPD

Efficacy of NIV Masks in COPD Patients With Chronic Respiratory Failure: A Randomized Controlled Cross Over Pilot

A randomized controlled pilot study to compare the efficacy and tolerability of a two different NIV masks on carbon dioxide in participants with stable chronic obstructive pulmonary disease (COPD) with chronic type II respiratory failure.

Inclusion Criteria:

• A doctor's diagnosis of COPD
• PtCO2 ≥45mmHg on transcutaneous monitor at baseline measure
• Oxygen saturation measured by pulse oximetry (SpO2) ≥85%
• Fits the study mask
• Can tolerate the therapy

Exclusion Criteria:

• FEV1/FVC ≥70%
• Body mass index >35
• Hypercapnia considered to be primarily due to Obesity Hypoventilation syndrome and/or Obstructive Sleep Apnea
• Any condition which makes NIV contra-indicated as per BTS guidelines based on clinical judgement