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The aim of this study is to investigate the effect of a six-week period personalised food intervention with prebiotic supplementation on intense exercise performance in healthy, recreationally active adults.
The study conforms to a randomized, single-blinded, placebo-controlled parallel study design.
a prebiotic supplement will be selected based on a participants gut microbiota. 1 sachet of prebiotic or placebo will be given twice a day over a period of 6 weeks.
Before the start of the study, a VO2max test will be performed. Subjects will bring faecal samples which is collected at home. A time to exhaustion of approximately 80% of their VO2max will be performed at baseline and after the 6 weeks intervention period.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Prebiotic intervention group | Experimental | Prebiotic supplementation |
|
| Placebo control group | Placebo Comparator | Maltodextrin |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Prebiotic | Dietary Supplement | 6 weeks of prebiotic supplementation twice a day |
|
| Measure | Description | Time Frame |
|---|---|---|
| Time to Exhaustion | Time on cycle ergometer until exhaustion | From baseline to end of the study (up to max 45 days) |
| Measure | Description | Time Frame |
|---|---|---|
| Gut microbiota composition | Composition of the gut microbiota by faecal sample analysis | From baseline to end of the study (up to max 45 days) |
| Plasma short chain fatty acids | Short chain fatty acids in plasma |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Freddy Troost, Dr. | Contact | +31(0)43 3884296 | f.troost@maastrichtuniversity.nl |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Maastricht University | Recruiting | Maastricht | Limburg | Netherlands |
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| ID | Term |
|---|---|
| D065817 | Congenital Microtia |
| ID | Term |
|---|---|
| D004427 | Ear Diseases |
| D010038 | Otorhinolaryngologic Diseases |
| D000013 | Congenital Abnormalities |
| D009358 | Congenital, Hereditary, and Neonatal Diseases and Abnormalities |
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| ID | Term |
|---|---|
| D056692 | Prebiotics |
| ID | Term |
|---|---|
| D004043 | Dietary Fiber |
| D004040 | Dietary Carbohydrates |
| D002241 | Carbohydrates |
| D011135 | Polysaccharides, Bacterial |
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The study conforms to a randomized, single-blinded, placebo-controlled parallel study design.
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| Placebo | Other | 6 weeks of maltodextrin supplementation twice a day |
|
| From baseline to end of the study (up to max 45 days) |
| Blood glucose | Fasted blood glucose | From baseline to end of the study (up to max 45 days) |
| Insulin | Fasted insulin | From baseline to end of the study (up to max 45 days) |
| Intestinal permeability by sugar test | Intestinal permeability measured by a sugar drink test | From baseline to end of the study (up to max 45 days) |
| D011134 |
| Polysaccharides |
| D005502 | Food |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019587 | Dietary Supplements |
| D019602 | Food and Beverages |