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| Name | Class |
|---|---|
| Cornell University | OTHER |
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This is a retrospective non-randomized clinical study of 60 patients total to assess the effects of SARS-CoV-2 infection and the SARS-CoV-2 vaccination. This study will have 2 arms evaluating the epigenomes of patients pre and post-exposure to one of the interventions. The first arm of the study will analyze 40 patients' epigenomes whose DNA methylation was examined pre and post SARS-CoV-2 infection. The second arm of this study is analyzing 20 patients' epigenomes whose DNA methylation was examined pre and post-injection of the SARS-CoV-2 vaccine.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients infected with SARS-CoV-2 | The first part of this study looks at the methylation patterns in individuals who have a baseline test taken of their DNA methylation patterns in their epigenome and then a follow-up test after they contracted SARS-CoV-2 | ||
| Patients who have received an mRNA vaccination | The second part of the study looks at the methylation patterns in individuals who have a baseline test taken of their DNA methylation patterns in their epigenome and then a follow-up test after SARS CoV-2 mRNA vaccine injection. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| SARS-CoV-2 mRNA vaccine | Biological | mRNA vaccine for COVID |
|
| Measure | Description | Time Frame |
|---|---|---|
| Methylation age clock testing | The DNA clocks that will be used to precisely measure aging is TruAge Biological Age test, which estimates biological age vs. chronological age | Change from baseline after COVID-19 infection |
| Methylation age clock testing | The DNA clocks that will be used to precisely measure aging is TruAge Biological Age test, which estimates biological age vs. chronological age | Change from baseline after COVID-19 mRNA vaccination |
| Measure | Description | Time Frame |
|---|---|---|
| Overall state of health | Questionnaire assessing overall health | Change from baseline after COVID-19 infection |
| Overall state of health | Questionnaire assessing overall health |
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Inclusion Criteria:
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Subjects that are healthy individuals and of any sex, ethnicity, and anyone above the age of 18 years old.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| TruDiagnostic | Lexington | Kentucky | 40503 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33557301 | Background | Bonek K, Roszkowski L, Massalska M, Maslinski W, Ciechomska M. Biologic Drugs for Rheumatoid Arthritis in the Context of Biosimilars, Genetics, Epigenetics and COVID-19 Treatment. Cells. 2021 Feb 4;10(2):323. doi: 10.3390/cells10020323. | |
| 32273594 | Background | Cao X. COVID-19: immunopathology and its implications for therapy. Nat Rev Immunol. 2020 May;20(5):269-270. doi: 10.1038/s41577-020-0308-3. |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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| ID | Term |
|---|---|
| C000722934 | CVnCoV COVID-19 vaccine |
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| Change from baseline after COVID-19 mRNA vaccination |
| 32393526 | Background | Corey L, Mascola JR, Fauci AS, Collins FS. A strategic approach to COVID-19 vaccine R&D. Science. 2020 May 29;368(6494):948-950. doi: 10.1126/science.abc5312. Epub 2020 May 11. No abstract available. |
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |