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Cardiac involvement has been described in Severe Acute Respiratory Syndrome - Coronavirus-2 (SARS-CoV-2) infection. Although there are no approved drugs to prevent or treat SARS-CoV-2 infection at present time, several medications used have the potential to increase QT interval and eventually provoke torsades de pointe. The investigators therefore create a study that include all patients with SARS-CoV-2 infection having an electrocardiogram (ECG). The investigators evaluate the percentage of patients with ECG abnormalities, describe the abnormalities and evaluate the occurrence of syncope, ventricular arrhythmia and corrected QT (cQT) interval modification in patients receiving treatment.
In patients with SARS-CoV-2 infection, the investigators analyze baseline ECG as well as follow-up ECG. Patients followed by Bordeaux University Hospital for COVID-19 can be included. ECG are digitized in the computerized patient file (DxCARE) for further analysis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| SARS-CoV-2 infection | This group includes patients prospectively included during their follow-up at the Bordeaux University Hospital for COVID-19, as well as retrospectively included patients whose follow-up for COVID-19 has been completed. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| ECG data analysis | Diagnostic Test | Baseline ECG as well as follow-up ECG are analysed |
|
| Measure | Description | Time Frame |
|---|---|---|
| Proportion of ECGs abnormalities in patients SARS-CoV-2 infection | Percentage of ECGs with abnormalities | Day 0 |
| Measure | Description | Time Frame |
|---|---|---|
| Evolution of PR, QRS and cQT interval | The evolution of interval is measured in seconds for patients receiving drugs interfering with cardiac electrophysiology for SARS-CoV-2 infection | Baseline and 1 month |
| Rate of syncope during treatment |
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Inclusion Criteria:
Exclusion Criteria:
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All patients with SARS-CoV-2 infection followed by Bordeaux University Hospital for COVID-19
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| Name | Affiliation | Role |
|---|---|---|
| frédéric Sacher, MD-PhD | University Hospital, Bordeaux | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bordeaux University Hospital | Pessac | 33600 | France |
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| ID | Term |
|---|---|
| D001145 | Arrhythmias, Cardiac |
| D000086382 | COVID-19 |
| D016171 | Torsades de Pointes |
| ID | Term |
|---|---|
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| Treatment data collect | Drug | Baseline treatment data as well as follow-up treatment data are collected |
|
| Biological check-up data collect | Biological | Baseline Biological check-up data as well as follow-up data are collected |
|
| Collection of clinical events of interest | Other | Clinical events of interest at the baseline as well as follow-up clinical events are collected |
|
The number of syncope is measured during the treatment
| Baseline and 1 month |
| Rate of cardiac death during treatment | The number of cardiac death is measured during the treatment | Baseline and 1 month |
| Rate of arrhythmia during treatment | The number of arrhythmia is measured during the treatment | Baseline and 1 month |
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
| D014777 | Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D017180 | Tachycardia, Ventricular |
| D013610 | Tachycardia |
| D000075224 | Cardiac Conduction System Disease |