The intrauterine device (IUD) is a reliable, safe, long acting, and effective contraceptive method . In spite of that, the pain associated with IUD insertion can be a cause against its insertion. Many researches have been conducted aiming to decrease the degree of pain during IUD insertion; these studies included medical and also technical methods.

The physicians usually prefer to insert the IUD during women's menses because the women are very unlikely to be pregnant and the insertion is easier and the pain is lower The easiness of IUD insertion is a very important issue that can increase women's satisfaction and decrease insertion pain.

Inclusion Criteria:

• Women aged 18-45 years
• Non-pregnant women
• Women who will come when there are non-menstruating.

Exclusion Criteria:

• Women received any analgesics or misoprostol in the 24 hours prior to insertion
• Women with any contraindications for IUD insertion
• Nulliparous women
• Women refuse to participate.
• Women have any contraindication of misoprostol.