Involvement of Polymorphonuclear Neutrophils and Platelets in Severe Form of COVID-19

Involvement of Polymorphonuclear Neutrophils and Platelets in Severe Form of COVID-19

The main objective is to quantify the population of reverse migrating neutrophils in patients with COVID-19.

This is a non-interventional transversal research whose main objective is to quantify the population of reverse migrating neutrophils in patients with COVID-19.

Design:

A multicentric (3 sites) clinical trial

Sample size :

200 patients

Population concerned:

Patients hospitalized in intensive care with SARS-CoV-2 infection confirmed by RT-PCR from a nasopharyngeal swab.

Duration of participation (treatment + follow-up): until the patient is discharged from the ICU and within 2 months top.

No interim analysis is planned. Analysis will be performed at the end of the study.

Inclusion Criteria:

• Patients admitted to the intensive care units of Saint-Antoine, Tenon and Pitié-Salpêtrière hospitals (Paris, France)
• With moderate to severe respiratory distress syndrome and SARS-CoV-2 infection confirmed by RT-PCR from a nasopharyngeal swab
• informed and not opposed to participation in research
• included within 4 hours following the paatient's admission

Exclusion Criteria:

• Patients under guardianship / curatorship
• Patients under AME