Hemodialysis (HD) triggers recurrent and cumulative ischemic insults to the brain and the heart. Cooled dialysate may have a protective effect on major organs and improve hemodynamic tolerability of dialysis. The aim of the study was to compare HD with cooled dialysate with routine dialysis in terms of hemodynamic stability and levels of high sensitivity Troponin I (hs-TnI) and N-terminal pro b-type natriuretic peptide (NTproBNP) post dialysis

Inclusion Criteria:

• Patients with renal insufficiency treated with dialysis for a period of at least three months.

Exclusion Criteria:

• Patients who experienced myocardial infarction during the three months prior to the start of the study
• Patients who underwent vascular surgery during the last month
• Patients who experienced chest pain at rest during the last week before the start of the trial - Patients who had to discontinue dialysis prematurely due to hemodynamic instability.