Study on Efficacy and Safety of Human Albumin in Burn Shock Recovery

Study on Efficacy and Safety of Human Albumin in Burn Shock Recovery

To explore the effects and safety of human albumin in burn shock recovery, and then provide a theoretical basis for its rational use.

A retrospective case-control study was conducted. Patients who admitted to the burn ward and needed fluid resuscitation during the period of January 2011 to December 2018 in our unit were identified. Patients were divided into two groups according to the severity of burns, the patients with a 20%<TBSA≤50% constituted the moderate and severe burn group, the patients with a TBSA>50% constituted the severest burn group, and then the patients who used albumin for resuscitation constituted the albumin group, the patients who did not use albumin constituted the control group. The primary outcome was mortality, and the secondary outcomes included hospital stay, ventilator supporting, fluid use, and complications.

Inclusion Criteria:

• Age ≥ 18
• TBSA≥ 20% （TBSA，the total burn area.）
• Admitted to hospital within 24 hours after injury.

Exclusion Criteria:

• STB ≥ 33 μ mol/L
• Cr ≥ 171 μ
• Urine output l< 500 ml / 24 h
• Pregnant and lactating women
• Severe combined injury
• Glucocorticoids users
• Immunosuppressants users
• Patients survived less than 48 hours