The Research of Human Cortex Cell Atlas | NCT04926987

Studies
The Research of Human Cortex Cell Atlas

NCT04926987

Sponsor

Second Affiliated Hospital, School of Medicine, Zhejiang University

Status

Unknown status

Last Update Posted

Jun 15, 2021Actual

Enrollment

20Estimated

Phase

Not provided

Conditions

Aging
Epilepsy
Trauma, Brain

Interventions

brain tissue single-cell sequencing

Countries

China

Protocol Section

Identification Module Status Module Sponsor/Collaborators Module Oversight Module Description Module Conditions Module Design Module Arms/Interventions Module Outcomes Module Eligibility Module Contacts/Locations Module References Module IPD Sharing Statement Module

Results Section

Participant Flow Module Baseline Characteristics Module Outcome Measures Module Adverse Events Module More Info Module

Annotation Section

Annotation Module

Document Section

Large Document Module

Derived Section

Miscellaneous Info Module Condition Browse Module Intervention Browse Module

Protocol Section

Identification Module

NCT ID

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Version Holder

Status Module

Record Verification Date

Jun 2021

Overall Recruitment Status or Expanded Access Status

Unknown status

Last Known Status

Recruiting

Delayed Posting

Not provided

Why Stopped

Not provided

Expanded Access Info

Start Date

Jun 1, 2020Actual

Primary Completion Date

Dec 30, 2022Estimated

Completion Date

Dec 30, 2022Estimated

First Submitted Date

May 29, 2021

First Submission Date that Met QC Criteria

Jun 14, 2021

First Posted Date

Jun 15, 2021Actual

Results Waived

Not provided

Results First Submitted Date

Not provided

Results First Submitted that Met QC Criteria

Not provided

Results First Posted Date

Not provided

Certification/Extension (aka Delayed Results) First Submitted Date

Not provided

Certification/Extension First Submitted that Passed QC Review

Not provided

Certification/Extension First Posted Date

Not provided

Last Update Submitted Date

Jun 14, 2021

Last Update Posted Date

Jun 15, 2021Actual

Description Module

Brief Summary

In this study, the single-cell transcriptome sequencing technology was used to study the transcriptome differences at the single-cell level in normal human brain, aging human brain, and epileptic brain.

Detailed Description

The human brain has about 100 billion cells and makes up neural networks.The abnormal activity of neurons can affect the operation of neural networks, leading to neurological diseases.With the coming of the age of global population aging, neurodegenerative diseases such as Alzheimer's, Parkinson's and Huntington's have become an increasing burden on human health.

Cells are the basic unit of brain. Understanding the mechanism of brain activities includes not only the mechanism of neural network, but also the self-regulation of its basic unit, that is, the regulation of gene expression based on brain activity.The abnormal expression and regulation of genes lead to the abnormal activities of the nervous system.Therefore, studying the regulation mechanism of gene expression at the cellular level is an important way to research brain diseases.The recent development of single-cell RNA-sequencing technology provides a possibility to understand the functioning mechanism of the brain at the cellular level.

Design Module

Study Type

Observational

Number of References to an Expanded Access Study

Not provided

Expanded Access Types

Not provided

Patient Registry

Target Follow-Up Duration

Not provided

Phases

Not provided

Interventional Study Design

Allocation

Not provided

Intervention Model

Biospecimen

Retention

Enrollment

20Estimated

Arms/Interventions Module

Arm Groups

Not provided

Interventions

Name	Type	Description	Arm Group Labels	Other Names
brain tissue single-cell sequencing	Other	Using single-cell sequencing to study the brain tissue single-cell transcriptome difference in aging, epilepsy, and mental disorders

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
single-cell RNA sequencing	single-cell RNA sequencing resultes of brain sample	1 Day of surgery

Secondary Outcomes

Not provided

Other Outcomes

Not provided

Eligibility Module

Eligibility Criteria

Inclusion Criteria:

Craniocerebral injury patients needing operative treatment
Treatment-resistant epilepsy patients needing resection surgery

Exclusion Criteria:

Vital signs unstable
Pregnancy
Tumor
Incomplete medical history, imaging and clinical diagnosis

Accepts Healthy Volunteers

Not provided

Sex

All

Sex/Gender Based

Not provided

Sex/Gender Description

Not provided

Minimum Age

18 Years

Maximum Age

80 Years

Standard Ages

AdultOlder Adult

Study Population

Craniocerebral injury patients needing operative treatment
Treatment-resistant epilepsy patients needing resection surgery.

Sampling Method

Non-Probability Sample

Contacts/Locations Module

Central Contacts

Name	Role	Phone	Extension	Email
Jianmin Zhang, M.D	Contact	86-13805722695		zjm135@zju.edu.cn

Overall Officials

Name	Affiliation	Role
Jianmin Zhang, M.D	Department of Neurosurgery	Study Chair
Junming Zhu, M.D	Department of Neurosurgery	Principal Investigator

Locations

Facility	Status	City	State	ZIP	Country	Contacts
2ndAffiliated Hospital, School of Medicine, Zhejiang University	Recruiting	Hangzhou	Zhejiang		China

Condition Browse Module

MeSH Terms

ID	Term
D004827	Epilepsy
D000070642	Brain Injuries, Traumatic

Ancestor Terms

ID	Term
D001927	Brain Diseases
D002493	Central Nervous System Diseases
D009422	Nervous System Diseases
D001930	Brain Injuries

Browse Leaves

Not provided

Browse Branches

Not provided