Characterizing the Effects of Family History of Alcoholism on Alcohol Analgesia

Characterizing the Effects of Family History of Alcoholism on Alcohol Analgesia

Self-medication of pain with alcohol is a common, yet risky, behavior. Evidence suggests family history of alcoholism may affect the degree to which alcohol use relieves pain, but the independent contributions of expectation and conditioning have not been previously studied. Interactive effects of sex and family history are also currently unclear. This project addresses this gap in knowledge and will inform further research and clinical/translational efforts for reducing risk associated with these behaviors.

Inclusion Criteria:

- Consume at least 1 drink/month over the past 6 months

Exclusion Criteria:

• History of chronic pain
• Current use of opioids
• Current major depression
• History of any psychotic disorder
• Undercontrolled hypertension or diabetes
• History of neurologic disease
• History of serious medical illness
• History of drug or alcohol dependence, including nicotine, or a pattern of hazardous alcohol use
• Safety concerns related to MRI (for example, implants or pacing devices)