Serum concentrations of Nemolizumab were analyzed using validated enzyme linked immunosorbent assay (ELISA).

Analysis was performed on Pharmacokinetic (PK) Set. The PK Set consisted of all participants who received at least 1 dose of study drug and have at least one measurable post-baseline concentration. Here, 'number analyzed' = participants with available data at each specified timepoint.

CL/F is apparent clearance of the drug from the serum, calculated as the drug dose divided area under the curve from time 0 extrapolated to infinite time [AUC (0-inf)]. Individual nemolizumab.

Analysis was performed on the PK Set. The PK Set consisted of all participants who received at least 1 dose of study drug and had at least one measurable post-baseline concentration.

Vd/F was calculated as dose divided by lambda_z *AUC(0-inf).

Analysis was performed on the PK Set. The PK Set consisted of all participants who received at least 1 dose of study drug and had at least one measurable post-baseline concentration.

Analysis was performed on the PK Set. The PK Set consisted of all participants who received at least 1 dose of study drug and had at least one measurable post-baseline concentration.

Analysis was performed on the PK Set. The PK Set consisted of all participants who received at least 1 dose of study drug and had at least one measurable post-baseline concentration.

Analysis was performed on the PK Set. The PK Set consisted of all participants who received at least 1 dose of study drug and had at least one measurable post-baseline concentration.

Analysis was performed on the PK Set. The PK Set consisted of all participants who received at least 1 dose of study drug and had at least one measurable post-baseline concentration.

AE defined as any untoward medical occurrence in clinical study participant administered a medicinal product which does not necessarily have causal relationship with this treatment. TEAEs defined as AEs occurring after first administration of study drug during the study. SAE was any untoward medical occurrence, in view of either Investigator or Sponsor, that resulted in death, was life-threatening, resulted in inpatient hospitalisation or prolongation of existing hospitalisation, resulted in persistent or significant disability/incapacity, was congenital anomaly/birth defect or was important medical event. AESI was noteworthy TEAE for study drug that was to be monitored closely and reported promptly. Relatedness to study drug was based on Investigator's discretion. AEs Leading to study treatment withdrawal and AEs Leading to study withdrawal will also be reported.

Analysis was performed on the safety set. The safety set consisted of all enrolled participants who received at least 1 dose of the study drug.

EASI assesses severity and extent of AD signs through a composite score of erythema, induration/population, excoriation, and lichenification. The severity was assessed on a scale of 0 (absent) to 3 (severe) for each of the 4 body areas: head/neck, trunk, upper limbs, and lower limbs, with half points allowed. The EASI score ranged from 0 to 72 with higher scores representing greater severity of atopic dermatitis.

Analysis was performed on the intent-to-treat (ITT) set. The ITT set consisted of all enrolled participants. Here, 'number analyzed' = participants with available data at each specified timepoint.

EASI assesses severity and extent of AD signs through a composite score of erythema, induration/population, excoriation, and lichenification. The severity was assessed on a scale of 0 (absent) to 3 (severe) for each of the 4 body areas: head/neck, trunk, upper limbs, and lower limbs, with half points allowed. The EASI score ranged from 0 to 72 with higher scores representing greater severity of atopic dermatitis.

Analysis was performed on the ITT set. The ITT set consisted of all enrolled participants. Here, 'number analyzed' = participants with available data at each specified timepoint.

EASI assesses severity and extent of AD signs through a composite score of erythema, induration/population, excoriation, and lichenification. The severity was assessed on a scale of 0 (absent) to 3 (severe) for each of the 4 body areas: head/neck, trunk, upper limbs, and lower limbs, with half points allowed. The EASI score ranged from 0 to 72 with higher scores representing greater severity of atopic dermatitis. EASI-50, EASI-75 and EASI-90 responders will be the participants who achieved greater than or equal to (>=) 50%, >=75% and >=90% overall improvement in EASI score respectively from baseline to Week 52.

Analysis was performed on the ITT set. The ITT set consisted of all enrolled participants. Here, 'number analyzed' = participants with available data at each specified timepoint.

IGA is a 5-point scale used by the investigator or trained designee to evaluate the global severity of AD. The Investigator reviewed the participant's skin and give a score of 0 (Clear), 1 (Almost clear), 2 (Mild), 3 (Moderate), or 4 (Severe). Here, higher score indicates severe outcome. Success was defined as an IGA of 0 [Clear] or 1 [Almost clear] and a >=2-points improvement from baseline. Number of participants with IGA success rate was reported for this outcome measure.

Analysis was performed on the ITT set. The ITT set consisted of all enrolled participants. Here, 'number analyzed' = participants with available data at each specified timepoint.

BSA affected by AD was assessed for each section of the body (the possible highest score for each region was: head and neck [9%], anterior trunk [18%], back [18%], upper limbs [18%], lower limbs [36%], and genitals [1%]) and reported as a percentage of all major body sections combined. The reported percentage of BSA was combined percentage of all major body sections.

Analysis was performed on the ITT set. The ITT set consisted of all enrolled participants. Here, 'number analyzed' = participants with available data at each specified timepoint.

Pruritus NRS is a scale that will be used by the participants to report the intensity of their pruritus (itch) during the last 24 hours. For maximum itch intensity: the scores were provided on a scale of 0 to 10, with 0 being 'no itch' and 10 being 'worst itch imaginable'. Higher scores indicated worse outcome.

Analysis was performed on the ITT set. The ITT set consisted of all enrolled participants. Here, 'number analyzed' = participants with available data at each specified timepoint.

Pruritus NRS is a scale that was used by the participants to report the intensity of their pruritus (itch) during the last 24 hours. For maximum itch intensity: the scores were provided on a scale of 0 to 10, with 0 being 'no itch' and 10 being 'worst itch imaginable'. Higher scores indicated worse outcome.

Analysis was performed on the ITT set. The ITT set consisted of all enrolled participants. Here, 'number analyzed' = participants with available data at each specified timepoint.

Pruritus NRS is a scale that was used by the participants to report the intensity of their pruritus (itch) during the last 24 hours. For maximum itch intensity: the scores were provided on a scale of 0 to 10, with 0 being 'no itch' and 10 being 'worst itch imaginable'. Higher scores indicated worse outcome.

Analysis was performed on the ITT set. The ITT set consisted of all enrolled participants. Here, 'number analyzed' = participants with available data at each specified timepoint.

Pruritus NRS is a scale that was used by the participants to report the intensity of their pruritus (itch) during the last 24 hours. For maximum itch intensity: the scores were provided on a scale of 0 to 10, with 0 being 'no itch' and 10 being 'worst itch imaginable'. Higher scores indicated worse outcome.

Analysis was performed on the ITT set. The ITT set consisted of all enrolled participants. Here, 'number analyzed' = participants with available data at each specified timepoint.

Pruritus NRS is a scale that was used by the participants to report the intensity of their pruritus (itch) during the last 24 hours. For maximum itch intensity: the scores were provided on a scale of 0 to 10, with 0 being 'no itch' and 10 being 'worst itch imaginable'. Higher scores indicated worse outcome.

Analysis was performed on the ITT set. The ITT set consisted of all enrolled participants. Here, 'number analyzed' = participants with available data at each specified timepoint.

The sleep disturbance NRS is a scale used by the participants to report the degree of their sleep loss related to AD. Participants were asked the following questions in their local language: how would you rate your sleep last night? On a scale of 0 to 10, with 0 being 'no sleep loss related to signs/symptoms of AD' and 10 being 'I cannot sleep at all due to the signs/symptoms of AD'. Higher scores indicated worse outcome.

Analysis was performed on the ITT set. The ITT set consisted of all enrolled participants. Here, 'number analyzed' = participants with available data at each specified timepoint.

The sleep disturbance NRS is a scale used by the participants to report the degree of their sleep loss related to AD. Participants were asked the following questions in their local language: how would you rate your sleep last night? On a scale of 0 to 10, with 0 being 'no sleep loss related to signs/symptoms of AD' and 10 being 'I cannot sleep at all due to the signs/symptoms of AD'. Higher scores indicated worse outcome.

Analysis was performed on the ITT set. The ITT set consisted of all enrolled participants. Here, 'number analyzed' = participants with available data at each specified timepoint.

Percentage of participants receiving any rescue therapy by rescue treatment was reported.

Analysis was performed on the ITT set. The ITT set consisted of all enrolled participants.

SCORAD is a clinical tool for assessing the severity and the extent of AD signs and symptoms. Extent and intensity of eczema as well as subjective signs (insomnia, etc.) are assessed and scored. Total score ranged from 0 (absent disease) to 103 (severe disease), a higher score indicated severe disease.

Analysis was performed on the ITT set. The ITT set consisted of all enrolled participants. Here, 'number analyzed' = participants with available data at each specified timepoint.

The DLQI is a validated 10-item questionnaire covering domains including symptoms/feelings, daily activities, leisure, work/school, personal relationships, and treatment. The participant rated each question ranging from 0 (not at all) to 3 (very much) and score ranged from 0 to 30. A higher total score indicated a poorer quality of life (QoL).

Analysis was performed on the ITT set. The ITT set consisted of all enrolled participants. Here, 'overall number of participants analyzed' = participants with available data for this outcome measure and 'number analyzed' = participants with available data at each specified timepoint.

The DLQI is a validated 10-item questionnaire covering domains including symptoms/feelings, daily activities, leisure, work/school, personal relationships, and treatment. The participant rated each question ranging from 0 (not at all) to 3 (very much) and score ranged from 0 to 30. A higher total score indicated a poorer QoL.

Analysis was performed on the ITT set. The ITT set consisted of all enrolled participants. Here, 'overall number of participants analyzed' = participants with available data for this outcome measure and 'number analyzed' = participants with available data at each specified timepoint. Data is reported for arm Cohort 2: Participants Aged 2-6 Years.

The POEM is a 7-item questionnaire that assessed disease symptoms (dryness, itching, flaking, cracking, sleep loss, bleeding and weeping) with a scoring system of 0 (absent disease) to 28 (severe disease). A high score indicated poor QOL.

Analysis was performed on the ITT set. The ITT set consisted of all enrolled participants. Here, 'overall number of participants analyzed' = participants with available data for this outcome measure and 'number analyzed' = participants with available data at each specified timepoint.

The relationship between nemolizumab serum concentrations and changes in PP-NRS score was established using population point estimate of IC50, where IC50 is the concentration leading to half of the maximum drug-induced reduction (Imax) in PP NRS.

Analysis was performed on PK Set. The PK Set consisted of all participants who received at least 1 dose of study drug and have at least one measurable post-baseline concentration.

The relationship between nemolizumab serum concentrations and changes in EASI score was established using population point estimate of IC50. Where, IC50 is the concentration leading to half of the maximum drug-induced reduction (Imax) in EASI score.

Analysis was performed on PK Set. The PK Set consisted of all participants who received at least 1 dose of study drug and have at least one measurable post-baseline concentration.

The relationship between nemolizumab serum concentrations and changes in IGA score was established using the population point estimate of the slope parameter.

Analysis was performed on PK Set. The PK Set consisted of all participants who received at least 1 dose of study drug and have at least one measurable post-baseline concentration.

ADA positive was defined as a sample that was evaluated as positive in both the ADA screening and confirmatory assays. ADA positive participants was defined as participants who had at least 1 positive ADA result.

Analysis was performed on the ITT set. The ITT set consisted of all enrolled participants.