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| ID | Type | Description | Link |
|---|---|---|---|
| 5R01ES023510-03 | U.S. NIH Grant/Contract | View source | |
| U01EB021923 | U.S. NIH Grant/Contract | View source | |
| P30ES007033 | U.S. NIH Grant/Contract | View source | |
| U2CES026561 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Environmental Health Sciences (NIEHS) | NIH |
| National Institute for Biomedical Imaging and Bioengineering (NIBIB) | NIH |
| The Yakima Valley Farm Workers Clinic | OTHER |
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This study seeks to reduce exposure to asthmagens in the homes of a community of Latino children residing in an area of intense agricultural production in Eastern Washington by testing the effectiveness of an intervention (high efficiency particulate air filter- HEPA portable room air cleaners) plus asthma education to reduce indoor measures of particulate matter, ammonia, improve clinically relevant measures of asthma health, and reduce biomarkers of inflammation.
Over the course of five years, this project's specific aims are as follows:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Intervention group | Other | Households are randomly assigned to the intervention group with asthma education and received two HEPA air cleaners designed to reduce PM and NH3. |
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| Control group | No Intervention | Households are randomly assigned to the control group. They only received the asthma education during the study period. These households receive a HEPA air cleaner at the end of the study. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| HEPA air cleaner | Device | Participants in the intervention group received two HEPA air cleaners per household. They were informed to place the HEPA air cleaners in the child's bedroom and the living room. Field staff provided and discuss how to use the air cleaner which promoted continuous operation of both air cleaners, keeping the child's bedroom door closed, and selected the highest fan speed. Typical use of the HEPA cleaners were questioned during the mid-study and final visits. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in particulate matter 2.5 (PM2.5) concentration | Indoor air sampling for PM2.5 collected over a 14-day period. MicroPEM (RTI International, Research Triangle Park, NC, USA) is turn on and left on for 14 days. Measurements collected at beginning and at 1 year after enrollment. | 1 year (study period) |
| Change in ammonia (NH3) concentration | Indoor air sampling for NH3 collected over a 14-day period. Ogawa passive sampler (Ogawa USA, Pompano Beach, Fl, USA) is left open for 14 days. Measurements collected at beginning and at 1 year after enrollment. | 1 year (study period) |
| Asthma Control Test | ACT score using the ACT questionnaire | At study enrollment |
| Clinical utilization | Caregivers were asked if child had a scheduled or unscheduled ("urgent") clinical visit with a doctor or health care provider, emergency department, or overnight hospitalization for asthma symptoms. Number and types of visits are reported. | One year (study period) |
| Inflammatory markers of asthma: Urinary leukotriene | Measured urinary leukotriene concentration and specific gravity in child urine sample. Measurements collected at enrollment, mid-study (4-6 months after enrollment), and end of study (1 year after enrollment) | 1 year (study period) |
| Inflammatory markers of asthma: Fractional exhaled nitric oxide | Portable NIOX VERO (Aerocrine Inc, Stockholm, Sweden) for direct measurement of fractional exhaled nitric oxide. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Catherine Karr, MD, PhD | University of Washington | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Yakima Valley Farmworkers Clinic | Yakima | Washington | 98902 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32721578 | Background | Masterson EE, Younglove LB, Perez A, Torres E, Krenz JE, Tchong French MI, Riederer AM, Sampson PD, Metwali N, Min E, Jansen KL, Aisenberg G, Babadi RS, Farquhar SA, Thorne PS, Karr CJ. The home air in agriculture pediatric intervention (HAPI) trial: Rationale and methods. Contemp Clin Trials. 2020 Sep;96:106085. doi: 10.1016/j.cct.2020.106085. Epub 2020 Jul 25. | |
| 32996146 | Background | Riederer AM, Krenz JE, Tchong-French MI, Torres E, Perez A, Younglove LR, Jansen KL, Hardie DC, Farquhar SA, Sampson PD, Karr CJ. Effectiveness of portable HEPA air cleaners on reducing indoor PM2.5 and NH3 in an agricultural cohort of children with asthma: A randomized intervention trial. Indoor Air. 2021 Mar;31(2):454-466. doi: 10.1111/ina.12753. Epub 2021 Jan 22. |
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Data has been shared with the NIH Chear Lab as part of U2CES02651
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| At study enrollment |
| Asthma exacerbation | Reviewed participant medical records for receipt of prescription for a course of oral corticosteroid. | One year (study period) |
| Lung function | Measured lung fuction using EasyOne spirometer (NDD Technologies, Andover, MA). Minimum of three exhalations with acceptable starts, complete exhalation, and no coughs until two exhalations with acceptable repeatability was achieved. | At study enrollment |
| 34980119 | Derived | Drieling RL, Sampson PD, Krenz JE, Tchong French MI, Jansen KL, Massey AE, Farquhar SA, Min E, Perez A, Riederer AM, Torres E, Younglove LR, Aisenberg E, Andra SS, Kim-Schulze S, Karr CJ. Randomized trial of a portable HEPA air cleaner intervention to reduce asthma morbidity among Latino children in an agricultural community. Environ Health. 2022 Jan 3;21(1):1. doi: 10.1186/s12940-021-00816-w. |