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In this study, investigators utilize a Artificial Intelligence (AI) supportive system to predict radiation proctitis for patients with pelvic cancers underwent radiotherapy. By the system, whether the participants achieve the radiation proctitis will be identified based on the radiomics features extracted from the post radiotherapy Magnetic Resonance Imaging (MRI) . The predictive power to discriminate the radiation proctitis individuals from non-radiation proctitis patients, will be validated in this multicenter, prospective clinical study.
This is a multicenter, prospective, observational clinical study for seeking out a better way to predict the radiation proctitis in patients with pelvic cancers based on the post-radiotherapy Magnetic Resonance Imaging (MRI) data. Patients who have been pathologically diagnosed as pelvic cancers will be enrolled from the Sixth Affiliated Hospital of Sun Yat-sen University, Sir Run Run Shaw Hospital and the Third Affiliated Hospital of Kunming Medical College. Patients with pelvic cancers who received radiotherapy will be enrolled and their post-radiotherapy MRI images will be used to predict their radiation proctitis or not. The clinical symptoms, endoscopic findings, imaging and histopathology as a standard. The predictive efficacy will be tested in this multicenter, prospective clinical study.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Artificial Intelligence | Diagnostic Test | investigators utilize a Artificial Intelligence (AI) supportive system to predict radiation proctitis for patients with pelvic cancers underwent radiotherapy |
| Measure | Description | Time Frame |
|---|---|---|
| The area under curve (AUC) of Receiver Operating Characteristic (ROC) curves of AI prediction system in prediction radiation proctitis | The area under curve (AUC) of Receiver Operating Characteristic (ROC) curves of AI prediction system in identifying the radiation proctitis candidates from non-radiation proctitis individuals among pelvic cancers underwent radiotherapy | baseline |
| Measure | Description | Time Frame |
|---|---|---|
| The specificity of AI prediction system in prediction radiation proctitis | The specificity of AI prediction system in identifying the radiation proctitis candidates from non-radiation proctitis individuals among pelvic cancers underwent radiotherapy | baseline |
| Measure | Description | Time Frame |
|---|---|---|
| The sensitivity of AI prediction system in prediction the radiation proctitis candidates | The sensitivity of AI prediction system in identifying the radiation proctitis candidates from non-radiation proctitis individuals among pelvic cancers underwent radiotherapy | baseline |
Inclusion Criteria:
Exclusion Criteria:
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pelvic cancers who underwent radiotherapy will be enrolled in our study.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Xinjuan Fan, MD | Contact | +86 13602442569 | fanxjuan@mail.sysu.edu.cn |
| Name | Affiliation | Role |
|---|---|---|
| Xinjuan Fan, MD | Sixth Affiliated Hospital, Sun Yat-sen University | Study Chair |
| Weidong Han, MD | Sir Run Run Shaw Hospital | Principal Investigator |
| Zhenhui Li, MD |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| the Sixth Affiliated Hospital of Sun Yat-sen University | Guangzhou | Guangdong | 510000 | China |
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| ID | Term |
|---|---|
| D010386 | Pelvic Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D001185 | Artificial Intelligence |
| ID | Term |
|---|---|
| D000465 | Algorithms |
| D055641 | Mathematical Concepts |
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| The Third Affiliated Hospital of Kunming Medical College. |
| Principal Investigator |
| the Sixth Affiliated Hospital of Sun Yat-sen University | Guangzhou | Guangdong | 510655 | China |
|
| The Third Affiliated Hospital of Kunming Medical College | Kunming | Yunnan | 650000 | China |
|
| Sir Run Run Shaw Hospital | Hangzhou | Zhejiang | 310000 | China |
|