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The aim of this study is to evaluate the anatomical and refractive parameters following a single-step transepithelial photo-refractive keratectomy (T-PRK) without the addition of mitomycin-C for the treatment of high myopia of 6 diopters or more.
In this retrospective study, 69 high myopic eyes of 6 diopters or more were treated in 38 patients by Trans-PRK with the SCHWIND Amaris 500E® excimer laser platform without the use of mitomycin-C. Several outcomes are measured in treated patients, such as postoperative uncorrected visual acuity (UCVA), best spectacle corrected visual acuity (BSCVA), efficacy, safety and predictability of the procedure, as well as corneal haze measurement. The patients are followed-up for 3 months.
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| Measure | Description | Time Frame |
|---|---|---|
| Postoperative uncorrected visual acuity (UCVA) at week 1 | Postoperative uncorrected visual acuity (UCVA) (logMAR) | Week 1 |
| Postoperative best spectacle corrected visual acuity (BSCVA) at week 1 | Postoperative best spectacle corrected visual acuity (BSCVA) (logMAR) | Week 1 |
| Postoperative uncorrected visual acuity (UCVA) at month 1 | Postoperative uncorrected visual acuity (UCVA) (logMAR) | Month 1 |
| Postoperative uncorrected visual acuity (UCVA) at month 3 | Postoperative uncorrected visual acuity (UCVA) (logMAR) | Month 3 |
| Postoperative best spectacle corrected visual acuity (BSCVA) at month 1 | Postoperative best spectacle corrected visual acuity (BSCVA) (logMAR) | Month 1 |
| Postoperative best spectacle corrected visual acuity (BSCVA) at month 3 | Postoperative best spectacle corrected visual acuity (BSCVA) (logMAR) | Month 3 |
| Measure | Description | Time Frame |
|---|---|---|
| Visual acuity efficacy index | The efficacy of the procedure was defined by the proportion of eyes with uncorrected visual acuity at 3 months greater than or equal to Log MAR 0.1 (or 8/10 on a decimal scale). The efficacy index was defined as the ratio between the mean uncorrected visual acuity at 3 months and the best corrected visual acuity preoperatively. A threshold of 80% was required to consider the surgery successful. |
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Inclusion Criteria:
Exclusion Criteria:
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This is a retrospective study conducted on the eyes of patients with high myopia (less than or equal to -6 diopters) associated or not with astigmatic less than 3 diopters operated by Trans-PRK with the SCHWIND Amaris 500E platform (SCHWIND eye-tech-solutions GmbH, Kleinostheim, Germany) in the CHR Metz-Thionville between January 1, 2018 and January 1, 2020
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| Name | Affiliation | Role |
|---|---|---|
| Jean Marc PERONE, MD | CHR Metz Thionville Hopital de Mercy | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier Metz Thionville | Metz | 57085 | France |
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| ID | Term |
|---|---|
| D005128 | Eye Diseases |
| D009216 | Myopia |
| D003318 | Corneal Opacity |
| ID | Term |
|---|---|
| D012030 | Refractive Errors |
| D003316 | Corneal Diseases |
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| 3 months |
| Visual acuity safety index | The safety of the procedure was defined as the proportion of eyes that lost 2 or more lines of visual acuity compared to the best preoperative corrected visual acuity. The safety index was defined as the ratio between the best corrected visual acuity 3 months postoperatively and the best corrected visual acuity preoperatively. An 80% threshold was chosen to consider the procedure safe. | 3 months |
| Predictability | Predictability was defined as the percentage of eyes having reached target refraction (± 0.5D) at the end of follow-up (3 months). | 3 months |
| Postoperative corneal haze measurement at week 1 | Corneal haze assessment was performed at each follow-up visit and reported on the Fantes scale
| Week1 |
| Postoperative corneal haze measurement at month 1 | Corneal haze assessment was performed at each follow-up visit and reported on the Fantes scale
| Month 1 |
| Postoperative corneal haze measurement at month 3 | Corneal haze assessment was performed at each follow-up visit and reported on the Fantes scale
| Month 3 |
| postoperative spherical equivalent | Percent of postoperative spherical equivalent D (SD) | 3 months |
| Postoperative refractive astigmatism at +/- 0.5D of target | Percent of eyes within +/- 0.5D of target | 3 months |
| Postoperative refractive astigmatism at +/- 1.0D of target | Percent of eyes within +/- 1.0D of target | 3 months |
| Complications | Percent of postoperative infections or epithelial healing | Up to 3 months |
| Patient sex | Sex ratio Men/Women (percent) | Before surgery |
| Patient age | Age (years) | Before surgery |
| Preoperative Myopia | Myopia (Diopters) | Before surgery |
| Preoperative Astigmatism | Astigmatism (Diopters) | Before surgery |
| Preoperative Spherical equivalence | Spherical equivalence (Diopters) | Before surgery |
| Preoperative best spectacle corrected visual acuity | BSCVA (logMAR) | Before surgery |
| Preoperative Keratometry | Keratometry (dipoters) | Before surgery |
| Preoperative central corneal thickness | central corneal thickness (µm) | Before surgery |
| Preoperative optical and transition zones | Optical and transition zones (mm) | Before surgery |
| Preoperative total ablation thickness | Total ablation thickness (µm) | Before surgery |