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To investigate the effect of nitrate supplementation on red blood cell function in patients with type 2 diabetes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Nitrate-rich beet root juice | Active Comparator | Nitrate-rich Beet root juice 70 ml bid |
|
| Placebo | Placebo Comparator | Nitrate-depleted beet root juice 70 ml bid |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Beet root juice | Dietary Supplement | 70 ml bid |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Percentage recovery of left ventricular function | Red blood cells are administered to an isolated rodent heart subjected to 25 min global ischemia and 60 min reperfusion. The percentage recovery during reperfusion is determined. | 1 week |
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Inclusion Criteria:
Type 2 diabetes
Exclusion Criteria:
Acute coronary syndrome Vegetarian diet Impaired renal function Absolute indication for proton pump inhibitor Ongoing treatment with organic nitrate Heart failure (ejection fraction <35%) Any condition that interferes with the possibility to fulfill the study protocol
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| John Pernow | Contact | +46704848361 | john.pernow@ki.se |
| Name | Affiliation | Role |
|---|---|---|
| John Pernow | Karolinska Institutet | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Karolinska Institutet, Karolinska University Hospital | Recruiting | Stockholm | 17176 | Sweden |
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| ID | Term |
|---|---|
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| Placebo juice |
| Dietary Supplement |
70 ml bid |
|
| D004700 | Endocrine System Diseases |