Effect of Postoperative Additive Systemic Steroids in CRSwNP

Prospective Randomized, Placebo-controlled Clinical Study to Study the Effect of Postoperative Additive Systemic Steroids in Chronic Rhinosinusitis With Nasal Polyps

This study investigate the additive effect of systemic postoperative steroids in patients with chronic rhinosinusitis (CRSwNP). All patients receive a functional endoscopic sinus surgery (FESS) followed by topical steroid spray for 3 months. Postoperatively, patients will be randomized to either an additional systemic steroid or a placebo for 1 month. Patients will be followed for 2 years. Effect on Nasal Polyp score (NPS), Lund-Kennedy-Score (LKS), recurrence rates, smell scores, Rhinosinusitis Disability Index (RSDI), Short-Form 36 (SF-36) and mucus/serum biomarkers will be measured.

Inclusion Criteria:

• CRSwNP
• refractory to medical therapy
• no previous sinus surgery
• Lund-Kennedy-Score ≥ 1
• Lund-Mackay-Score ≥ 10

Exclusion Criteria:

• ciliary impairment
• autoimmune disease
• cystic fibrosis
• immunodeficiency