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The cemented femoral stem have impact on increase on systemic parameters.
Evaluation of the level of histamine, C-reactive protein (CRP) and leukocytes formula, IL1b, TNF alpha, IL6 and the reflection of changes of these parameters in the intra-operative course of hip replacement.
Implantation of total endoprosthesis is a very common surgical procedure and is performed with and without bone cement.
In most cases during cementation of the femoral component there are changes in blood pressure, SpO2, heartbeat and other vital parameters which can cause complications during surgery.
Comparing the system parameters between the two groups and deriving these results will help the medical staff to be more professionally prepared to resolve possible complications.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Correlation of intramedullary pressure and systemic inflammatory parameters in cemented THA |
| ||
| Correlation of intramedullary pressure and systemic inflammatory parameters in non cemented THA |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Hip Replacement | Procedure | The hip replacement surgery is when a damaged hip is replaced with artificial one |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change of systemic parameters during and after hip replacement (Histamine) | Analysis of the impact of cement in different laboratory parameters such as histamine | The measurement of these laboratory parameters 5 minutes before and 10 minutes after surgical procedures will reflect the impact of cements in the eventual post-surgical complications, such are embolism and other complications. |
| Change of systemic parameters during and after hip replacement (CRP) | Analysis of the impact of cement in different laboratory parameters such as C-reactive protein (CRP) | The measurement of these laboratory parameters 5 minutes before and 10 minutes after surgical procedures will reflect the impact of cements in the eventual post-surgical complications, such are embolism and other complications. |
| Change of systemic parameters during and after hip replacement (Leukocytes formula) | Analysis of the impact of cement in different laboratory parameters such as changes of leukocytes formula | The measurement of these laboratory parameters 5 minutes before and 10 minutes after surgical procedures will reflect the impact of cements in the eventual post-surgical complications, such are embolism and other complications. |
| Change of systemic parameters during and after hip replacement (IL1b) | Analysis of the impact of cement in different laboratory parameters such as IL1b | The measurement of these laboratory parameters 5 minutes before and 10 minutes after surgical procedures will reflect the impact of cements in the eventual post-surgical complications, such are embolism and other complications. |
| Change of systemic parameters during and after hip replacement (TNF alpha) | Analysis of the impact of cement in different laboratory parameters such are TNF alpha |
| Measure | Description | Time Frame |
|---|---|---|
| Difference of arterial pressure | Difference of arterial pressure after implantation of femoral component | The changes will be measured 5 minutes before implantation and during first 10 minutes after implantation |
| Difference of changes of Leukocyte formula |
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Inclusion Criteria:
The inclusion criteria were as follows:
Exclusion Criteria:
The exclusion criteria were patients with:
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Patients are from the waiting list for surgery. All are included in the study with their consent The femoral component cemented or non-cemented is realized based on bone quality, age and its testing during surgery.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Skender Ukaj, MD | Contact | 0038344603609 | skender.ukaj@uni-gjk.org |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Clinical Center of Kosovo | Recruiting | Pristina | 10000 | Kosovo |
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| ID | Term |
|---|---|
| D019644 | Arthroplasty, Replacement, Hip |
| D001178 | Arthroplasty |
| ID | Term |
|---|---|
| D019643 | Arthroplasty, Replacement |
| D019637 | Orthopedic Procedures |
| D013514 | Surgical Procedures, Operative |
| D019651 | Plastic Surgery Procedures |
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Evaluation of the level of histamine, C-reactive protein (CRP) and leukocytes formula, IL1b, TNF alpha, IL6 and the reflection of changes of these parameters in the intra-operative course of hip replacement.
|
| The measurement of these laboratory parameters 5 minutes before and 10 minutes after surgical procedures will reflect the impact of cements in the eventual post-surgical complications, such are embolism and other complications. |
| Change of systemic parameters during and after hip replacement (IL6) | Analysis of the impact of cement in different laboratory parameters such as IL6. | The measurement of these laboratory parameters 5 minutes before and 10 minutes after surgical procedures will reflect the impact of cements in the eventual post-surgical complications, such are embolism and other complications. |
Difference of changes of Leukocyte formula after implantation of femoral component |
| The blood will be taken from patience 1 hour before and Post Operative Day One |
| Difference of SpO2 | Difference of SpO2 after implantation of femoral component The changes will be measured by the device monitor connected to patient | The changes will be measured 5 minutes before implantation and during first 10 minutes after implantation] |
| D019919 | Prosthesis Implantation |