Background:

The current screening techniques for colorectal cancer include colonoscopy, fecal occult blood, and high-risk factor questionnaires. However, the colorectal cancer screening technology that has been widely used at present cannot take into account sensitivity and specificity, and the tumor detection rate is low.

The purpose of research:

1. Build a new type of population colorectal cancer precision screening technology program;
2. Improve the detection rate of colorectal cancer in the population by new methods (compared with the existing domestic advanced technology) by ≥20%, and improve the specificity of colorectal cancer screening by ≥15% without significantly reducing the sensitivity.

Inclusion Criteria:

Age: 40-74 years old

Exclusion Criteria:

1. Combine severe disorders to make it unsuitable for colonoscopy
2. Combine other tumors
3. Mental and behavioral abnormalities do not cooperate with the screener
4. Researchers believe that other reasons are not suitable for enrollment

Individuals of 40-74 years old in non-high incidence of colorectal cancer areas(hospital outpatient population, community population in non-high-risk areas) .