Hereditary spastic paraparesis type 11 (SPG11) is caused by mutations in the SPG11 gene that produces spatacsin, a protein involved in lysosomal function.

Several experiments on subjects affected by neurodegenerative diseases with dysfunction of the autophagic-lysosomal system show that trehalose improves the pathological phenotype. This evidence indicates that trehalose could be used in patients with SPG11 to try to prevent the accumulation of glycosphingolipids at the lysosomal level and induce the genesis of new lysosomes. This study aims to record clinical data of 20 patients with SPG11 who take trehalose during 12 months.

Inclusion Criteria:

• Confirmed diagnosis of SPG11
• Written signed informed consent

Exclusion Criteria:

• Diagnosis of other concomitant neurodegenerative diseases
• taking other experimental drugs within 30 days of the first Study visit (T0) and during the study
• Refusal to sign informed consent

Subjects will be enrolled in our centre (IRCCS Fondazione Stella Maris) as part of the primary care during regular visits.