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Lack of institutional resources to conduct project, increased cost of conducting project due to workarounds with resources not being available, and COVID-19 pausing human subjects data collection in 2020.
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The purpose of the study is to learn about how type of exercise influences measures of appetite regulation.
The primary objective of this study is to understand the relationship between exercise modality and appetite regulation in a population with pre-diabetes. The study includes a screening visit to ensure eligibility of participants, baseline assessments, a resistance exercise intervention, and post intervention measurements. The variables of interest include, but are not limited to, hormonal responses to exercise training pertaining to appetite, food cravings, appetite ratings. activity levels, body composition, and ten repetition-max strength. The aim of this study is to better understand the mechanisms involved in the correlation or causation of any improvements in fitness and appetite regulation in a cohort with pre-diabetes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Resistance Exercise | Experimental | Resistance exercise will be training all major muscle groups 2x/week (2 days upper body, 2 days lower body) at 40-50% 1 repetition max (RM; estimated from 10 RM baseline testing) for 3 sets of 10-12 reps. This equals 4x/week for the 3 week intervention period. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Resistance Exercise | Behavioral | Increasing strength and fitness and thereby influencing hormones and perceptions involved in appetite regulation. |
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| Measure | Description | Time Frame |
|---|---|---|
| Changes in Appetite Rating | Hunger/Satiety before/after consumption of a meal | Baseline: Pre-Meal , 30 minutes, 60 minutes, 90 minutes, and 120 minutes post meal / Post-intervention(Week 4) :Pre-Meal, 30 minutes, 60 minutes, 90 minutes ,and 120 minutes post meal |
| Changes in Hormonal Response to Feeding | Assessment of Ghrelin levels analyzed in blood samples before/after feeding. | Baseline: Pre-Meal , 30 minutes, 60 minutes, 90 minutes, and 120 minutes post meal / Post-intervention(Week 4) :Pre-Meal, 30 minutes, 60 minutes, 90 minutes ,and 120 minutes post meal |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in Body Composition | Measured via BodPod | Baseline and Post-intervention(Week 4) |
| Changes in Maximal Strength | Measurement via 10 repetition-max testing. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Tanya M Halliday, PhD, RD | University of Utah | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Utah | Salt Lake City | Utah | 84112 | United States |
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| ID | Term |
|---|---|
| D011236 | Prediabetic State |
| D001070 | Appetitive Behavior |
| D018149 | Glucose Intolerance |
| ID | Term |
|---|---|
| D003920 | Diabetes Mellitus |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D055070 | Resistance Training |
| ID | Term |
|---|---|
| D005081 | Exercise Therapy |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
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Participants are randomly assigned to one of the two intervention groups.
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| Baseline and Post-intervention(Week 4) |
| Changes in Physical Activity Levels | Measured via ActivPal Monitor | Baseline and Post-intervention(Week 4) |
| Changes in Food-Related Behaviors | Evaluated via the Food Craving Inventory | Baseline and Post-intervention(Week 4) |
| Changes in Food-Related Behaviors | Evaluated via Three-Factor Eating Questionnaire | Baseline and Post-intervention(Week 4) |
| Changes in Food-Related Behaviors | Evaluated via the Weight Efficacy Lifestyle Questionnaire | Baseline and Post-intervention(Week 4) |
| Change in Ad libitum Energy Intake - In lab | In lab ad libitum buffet lunch (via weigh and measure methodology) | Baseline and Post-intervention(Week 4) |
| Changes in Ad libitum Energy Intake - Free Living | 3 days of free-living ad libitum energy intake (via self-report) | Baseline and Post-intervention(Week 4) |
| D004700 | Endocrine System Diseases |
| D001522 | Behavior, Animal |
| D001519 | Behavior |
| D006943 | Hyperglycemia |
| D005791 |
| Patient Care |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |