Prediction of Lymph Node Invasion for Prostate Adenocarcinoma

Prediction of Lymph Node Invasion in Patients Operated on for Prostate Adenocarcinoma

Despite lymph node involvement (LNI) being one of the main prognostic factors in patients with prostate cancer (PCa), pelvic lymph node irradiation remains debated, possibly due to an insufficient selection of patients. Significant advances in LNI risk modelling have been achieved with the addition of visual interpretation of magnetic resonance imaging (MRI) data, but it is likely that quantitative analysis could further improve prediction models. In this study, the investigators aimed to develop and internally validate a novel LNI risk prediction model based on radiomic features extracted from pre-operative multimodal MRI.

Inclusion Criteria:

• Histologically proven adenocarcinoma of the prostate treated by prostatectomy with extensive lymph node dissection
• Available pre-operative +/- PET choline

Exclusion Criteria:

• Unanalyzable pre-operative MRI