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Despite lymph node involvement (LNI) being one of the main prognostic factors in patients with prostate cancer (PCa), pelvic lymph node irradiation remains debated, possibly due to an insufficient selection of patients. Significant advances in LNI risk modelling have been achieved with the addition of visual interpretation of magnetic resonance imaging (MRI) data, but it is likely that quantitative analysis could further improve prediction models. In this study, the investigators aimed to develop and internally validate a novel LNI risk prediction model based on radiomic features extracted from pre-operative multimodal MRI.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Absence of invaded lymph node after extensive lymph node dissection | Absence of invaded lymph node after extensive lymph node dissection | ||
| Presence of invaded lymph node after extensive lymph node dissection | Presence of invaded lymph node after extensive lymph node dissection |
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| Measure | Description | Time Frame |
|---|---|---|
| Predicted risk of lymph-node involvement vs Briganti 2017 | Comparison between the predicted risk of lymph node involvement based on the new algorithm and the predicted risk with the Briganti 2017 | immediately after the intervention/procedure/surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Predicted risk of lymph-node involvement vs Briganti 2012, Briganti 2018, Briganti 2019 and MSKCC | Comparison between the predicted risk of lymph node involvement based on the new algorithm and the predicted risk with the Briganti 2012, Briganti 2018, Briganti 2019 and MSKCC | immediately after the intervention/procedure/surgery |
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Inclusion Criteria:
Exclusion Criteria:
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The population consists of patients operated on for an adenocarcinoma of the prostate by radical prostatectomy with extensive lymph node dissection and for whom pre-operative MRI is available and analyzable.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ulrike Ulrike Schick | Contact | +33298223398 | ulrike.schick@chu-brest.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHRU Brest | Recruiting | Brest | 29200 | France |
All collected data that underlie results in a publication
Data will be available beginning three month and ending five years following the publication
Data access requests will be reviewed by the internal committee of Brest UH. Requestors will be required to sign and complete a data access agreement.
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| Biochemical recurrence free survival |
Prediction of Biochemical recurrence free survival |
| immediately after the intervention/procedure/surgery |
| Extra-prostatic disease | Prediction of Extra-prostatic disease | immediately after the intervention/procedure/surgery |
| Seminal vesicle invasion | Prediction of Seminal vesicle invasion | immediately after the intervention/procedure/surgery |
| Automatic segmentation of the index lesion | Comparison between a manual segmentation of the index lesion and an automatic segmentation | immediately after the intervention/procedure/surgery |