Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Chikungunya is an infectious disease caused by an alphavirus transmitted by the Aedes mosquitoes which has known a worldwide expansion since its re-emergence in 2004. Regarding to an unprecedented epidemic, Reunionese pediatricians described in 2005-2006 a vertical maternal-fetal transmission of this virus, at the time of childbirth. Since then, this mode of transmission has been widely confirmed, with an absolute risk estimated between 15.5% and 48.3%. The main consequences for the child are neuromotor, neurosensory or neurocognitive. They were studied around the age of 2 in 33 children in the CHIMERE cohort, as well as at the age of 5 in a small fraction of these children followed at the C.A.M.S.P (Center for Early Medico-Social Action). The results suggested an overall delay in psychomotor acquisitions secondary to neonatal infection, affecting the functions of the prefrontal region (in particular coordination and language). Performance was correlated with the severity of the clinical presentation (more severe in case of encephalitis or encephalopathy) while remaining suboptimal in children with uncomplicated infection. During neurodevelopmental monitoring, other disturbing traits complemented the spectrum of problems presented by these children, such as microcephaly, cerebral palsy, epilepsy, interaction disorder or attention deficit disorder. At around age 10, the investigators reassessed 21 of these children using the Childhood Cognitive Function and Learning (EDA) screening test. The investigators would now like to confirm and characterize their impairments using a battery of confirmatory tests around the age of 13.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exposed arm | Other | child infected with chikungunya virus during childbirth |
|
| Non-exposed arm | Other | child not infected with the chikungunya virus at the time of childbirth, verifying the matching criteria specified |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| OPHTHALMOLOGICAL ASSESSMENT | Other | assessment of eye mobility (search for heterophoria or strabismus), visual acuity, visual fields, external structures and funduscopic examination |
| Measure | Description | Time Frame |
|---|---|---|
| Total intelligence quotient | Evaluation of total intelligence quotient with Wechsler Intelligence Scale for Children-5 | Month 3 (+/- 1 month) |
Not provided
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Affiliation | Role |
|---|---|---|
| Raphaelle SARTON, MD | CHU de La Réunion | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU de La Réunion | Saint-Pierre | 97410 | Reunion |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42205143 | Derived | Sarton R, Mery MO, Carbonnier M, Renouil M, Morice C, Medjane S, Bintner M, Boumahni B, Gerardin P. Long-term neurodevelopmental outcomes of children perinatally infected with chikungunya: the CHIK13+ matched cohort study on Reunion Island. EClinicalMedicine. 2026 May 18;95:103975. doi: 10.1016/j.eclinm.2026.103975. eCollection 2026 May. |
Not provided
Not provided
Not provided
| ID | Term |
|---|---|
| D065632 | Chikungunya Fever |
| ID | Term |
|---|---|
| D018354 | Alphavirus Infections |
| D001102 | Arbovirus Infections |
| D000079426 | Vector Borne Diseases |
| D007239 | Infections |
Not provided
Not provided
| ID | Term |
|---|---|
| D009483 | Neuropsychological Tests |
| ID | Term |
|---|---|
| D011581 | Psychological Tests |
| D004191 | Behavioral Disciplines and Activities |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| NEUROPSYCHOLOGICAL ASSESSMENT | Other | completion of WISC-5, Vineland Adaptive Behavior Scale II and Strengths and Difficulties Questionnaire |
|
| D000096724 |
| Mosquito-Borne Diseases |
| D014777 | Virus Diseases |
| D014036 | Togaviridae Infections |
| D012327 | RNA Virus Infections |