Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| St. Anne's University Hospital Brno, Czech Republic | OTHER |
| Regional Hospital Liberec | OTHER |
Not provided
Not provided
Not provided
The main goal of the project is to prove that ultra-high-frequency ECG (UHF-ECG) can be used as a diagnostic tool that allows the prediction of patients susceptible to the negative effect of right ventricular myocardial pacing. The prediction will be based on the assessment of electrical dyssynchrony and local depolarization durations of left ventricular depolarization emerging during right ventricular pacing. If proved to be valid in left ventricular negative remodeling prediction, UHF-ECG-derived parameters of ventricular dyssynchrony could be used as markers allowing a lead placement optimization during an implant procedure. This information can help the operator to identify patients with the urgent need for physiological pacing (HB or LBBp) and patients in which a right ventricular myocardial pacing is sufficient and will not lead to the development of the negative left ventricular remodeling.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| myocardial pacing group | patients with the pacing lead placed into the right ventricle to obtain myocardial capture |
| |
| physiological pacing group | patients with the pacing lead placed into the His bundle or left bundle branch area |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| pacemaker implantation | Device | pacemaker implantation |
|
| Measure | Description | Time Frame |
|---|---|---|
| negative remodeling prediction |
| 1 year from randomization |
| Measure | Description | Time Frame |
|---|---|---|
| RV myocardial to physiological pacing comparison | left ventricular ejection fraction comparison between low risk right ventricular myocardial to physiological pacing group | 2 years from randomization |
| UHF-ECG prediction of clinical outcome |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
360 patients with an indication for permanent pacing due to permanent conduction disease of/below the AV node
Not provided
Not provided
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Karol Curila | Prague | 10000 | Czechia |
Not provided
Not provided
Not provided
Not provided
occurence of death, myocardial infarction, worsening heart failure or upgrade to resynchronization therapy will be predicted by the duration of UHF-ECG electrical dyssynchrony, and/or left ventricular lateral wall delay and/or V6d parameter
| 3 years from randomization |