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| Name | Class |
|---|---|
| The University of Texas at Arlington | OTHER |
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This study evaluates the role of endothelin in insulin stimulated vasodilation and glucose uptake. The subjects will complete an hyperinsulinemic euglycemic clamp with and without blockade of the endothelin receptors.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Type 2 diabetics | Experimental | BQ123 (25 nmol/min), BQ788 (25 nmol/min) |
|
| Healthy controls | Experimental | BQ123 (25 nmol/min), BQ788 (25 nmol/min) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Insulin clamp | Drug | Continous infusion insulin + glucose |
|
| Measure | Description | Time Frame |
|---|---|---|
| Glucose infusion rate | Glucose infusion rate required to maintain euglycemia during insulin clamp with and without endothelin blockade | 3.5 hours |
| Leg blood flow | Effect of endothelin receptor blockade on leg blood flow (ultrasound Doppler) during insulin clamp with and without endothelin blockade | 3.5 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Stefan Mortensen, DMSc | Professor | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cardiovascular and Renal Research | Odense | 5000 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35084435 | Derived | Young BE, Padilla J, Finsen SH, Fadel PJ, Mortensen SP. Role of Endothelin-1 Receptors in Limiting Leg Blood Flow and Glucose Uptake During Hyperinsulinemia in Type 2 Diabetes. Endocrinology. 2022 Mar 1;163(3):bqac008. doi: 10.1210/endocr/bqac008. |
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| ID | Term |
|---|---|
| C072247 | cyclo(Trp-Asp-Pro-Val-Leu) |
| C086539 | BQ 788 |
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| BQ123 | Drug | Continuous infusion of Insulin + glucose + BQ123 |
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| BQ123 + BQ788 | Drug | Continous infusion of insulin + glucose + BQ123 + BQ788 |
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