Cellular Senescence and COVID-19 Long-Hauler Syndrome | NCT04903132

Studies
Cellular Senescence and COVID-19 Long-Hauler Syndrome

NCT04903132

Sponsor

Mayo Clinic

Status

Active, not recruiting

Last Update Posted

Jun 23, 2026Actual

Enrollment

200Estimated

Phase

Not provided

Conditions

SARS-CoV2 Infection

Interventions

Not provided

Countries

United States

Protocol Section

Identification Module Status Module Sponsor/Collaborators Module Oversight Module Description Module Conditions Module Design Module Arms/Interventions Module Outcomes Module Eligibility Module Contacts/Locations Module References Module IPD Sharing Statement Module

Results Section

Participant Flow Module Baseline Characteristics Module Outcome Measures Module Adverse Events Module More Info Module

Annotation Section

Annotation Module

Document Section

Large Document Module

Derived Section

Miscellaneous Info Module Condition Browse Module Intervention Browse Module

Protocol Section

Identification Module

NCT ID

Results Section

No data available

No data is available for this block.

Annotation Section

No data available

No data is available for this block.

Document Section

No data available

No data is available for this block.

Derived Section

Miscellaneous Info Module

Version Holder

Status Module

Record Verification Date

Jun 2026

Overall Recruitment Status or Expanded Access Status

Active, not recruiting

Last Known Status

Not provided

Delayed Posting

Not provided

Why Stopped

Not provided

Expanded Access Info

Start Date

Mar 1, 2021Actual

Primary Completion Date

Dec 2026Estimated

Completion Date

Dec 2026Estimated

First Submitted Date

May 24, 2021

First Submission Date that Met QC Criteria

May 24, 2021

First Posted Date

May 26, 2021Actual

Results Waived

Not provided

Results First Submitted Date

Not provided

Results First Submitted that Met QC Criteria

Not provided

Results First Posted Date

Not provided

Certification/Extension (aka Delayed Results) First Submitted Date

Not provided

Certification/Extension First Submitted that Passed QC Review

Not provided

Certification/Extension First Posted Date

Not provided

Last Update Submitted Date

Jun 18, 2026

Last Update Posted Date

Jun 23, 2026Actual

Label	Type	Description	Intervention Names
Longhauler's Syndrome Cohort		Subject's with longhaulers
Control Cohort		Control cohort will not have had a known case of COVID-19 or Longhauler's syndrome
COVID Control Cohort		Subjects who have had COVID-19 but no known Longhauler's syndrome

Outcomes Module

Primary Outcomes

Measure	Description	Time Frame
Correlation between features of Long-Hauler Syndrome with markers of cellular senescence and SASP factors	If a correlation between features of Long-Hauler Syndrome with markers of cellular senescence and SASP factors can be demonstrated, or SASP factors are higher in Long-Hauler Syndrome clinic patients than age- and sex-matched controls (using archived samples) in this pilot study, a protocol will be submitted to the IRB for a trial in Long-Hauler Syndrome patients of senolytic drugs.	6 months

Secondary Outcomes

Not provided

Other Outcomes

Not provided

Eligibility Module

Eligibility Criteria

Longhauler's Cohort -

Inclusion Criteria:

Ability to give informed consent or LAR.
At least 18 years old.
Ability of subject or LAR to read and speak the English language.
Positive PCR or antibody test within 12 months of initial study visit.
Patient of the Long-Hauler Syndrome clinic and differential diagnosis of Long-Hauler Syndrome.

Exclusion Criteria:

Any potential participant who refuses medical record review.
Pregnant females.
Incarcerated individuals.
Inability to cooperate or any medical condition that, in the opinion of the investigator, interferes with the evaluation of the study objectives or increases the subject's risk by participating in the study.

Control Cohort -

Inclusion Criteria:

Ability to give informed consent
At least 18 years old
Ability of subject to read and speak the English language

Exclusion Criteria:

Known case of COVID-19.
Any potential participant who refuses medical record review.
Pregnant females.
Incarcerated individuals.
Inability to cooperate or any medical condition that interferes with the evaluation of the study objectives or increases the subject's risk by participating in the study.

COVID-19 Control Cohort

Inclusion Criteria:

Ability to give informed consent.
At least 18 years old.
Ability of subject to read and speak the English language.
Known case of COVID-19.

Exclusion Criteria:

Known Longhauler's syndrome/Post-COVID
Any potential participant who refuses medical record review.
Pregnant females.
Incarcerated individuals.
Inability to cooperate or any medical condition that interferes with the evaluation of the study objectives or increases the subject's risk by participating in the study.

Accepts Healthy Volunteers

Yes

Sex

All

Sex/Gender Based

Not provided

Sex/Gender Description

Not provided

Minimum Age

18 Years

Maximum Age

Not provided

Standard Ages

AdultOlder Adult

Study Population

Longhauler's Cohort: Patients must be at least 18 years or older, have a positive PCR or antibody test within six months, and report any ongoing symptoms associated with Post-COVID or Long-Haulers Syndrome.

Control Cohort: Patients must be at least 18 years or older, have not had a known case of COVID-19 or Longhauler's syndrome.

COVID Control Cohort: Patients must be at least 18 years or older and have had COVID-19 but no known Longhauler's syndrome.

Sampling Method

Non-Probability Sample

ID	Term
D011024	Pneumonia, Viral
D011014	Pneumonia
D012141	Respiratory Tract Infections
D007239	Infections