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The aim of this study is to evaluate the efficacy of non-surgical periodontal therapy with supportive home oral care for the treatment of peri-implant mucositis.
Patients with bilateral implants with peri-implant mucositis will undergo professional dental hygiene with ultrasonic handpiece and manual scaler, followed by the application of glycine Airflow powders. Then, patients will be randomly divided into two groups: the Trial Group will undergo a split-mouth application of chlorhexidine gel 1% for quadrants 1 and 4 and of Biorepair Periogel 0.12% for quadrants 2 and 3, with one daily home application for the following 15 days after the visits and the use of Biorepair Parodontogel toothpaste; the control Group will not use any gels.
The improvement of peri-implant mucositis will be evaluated between the two groups and differences between the two gels will be assessed, if present.
The aim of this study is to evaluate the efficacy of non-surgical periodontal therapy with supportive home oral care for the treatment of peri-implant mucositis.
Patients with bilateral implants with peri-implant mucositis will undergo professional dental hygiene with ultrasonic handpiece and manual scaler, followed by the application of glycine Airflow powders. Then, patients will be randomly divided into two groups:
The improvement of peri-implant mucositis will be evaluated between the two groups and differences between the two gels will be assessed, if present, evaluating periodontal indices at the baseline, after three months and after six months.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Trial Group | Experimental | Patients from this group will use chlorhexidine Biorepair gel and toothpaste for home oral care. |
|
| Control Group | Active Comparator | Patients from this group will not use chlorhexidine and Biorepair gels and toothpastes, but will perform home oral care with standard toothpastes. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Chlorhexidine and Biorepair gel and toothpaste application | Other | Split-mouth application of chlorhexidine gel 1% (quadrants 1 and 4) and Biorepair Periogel (quadrants 2 and 3) after professional dental hygiene. Home oral care will be continued with chlorhexidine 0,12% gel and Biorepair Periogel in the same quadrants, for the following 15 days from the visits, together with the use of Biorepair Parodontogel toothpaste. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in BOP - Bleeding On Probing | Dichotomous scoring (yes/no) | Baseline, 1, 3 and 6 months. |
| Change in GBI - Gingival Bleeding Index (percentage) | Site-specific assessment of the presence or absence of gum bleeding after the insertion of the periodontal probe for the detection of PPD, detected on 6 sites. The number of bleeding sites is divided per the total number of probed sites; the ratio is multiplied X 100. | Baseline, 1, 3 and 6 months. |
| Change in suppuration | Dichotomous scoring (yes/no) | Baseline, 1, 3 and 6 months. |
| Change in marginal mucosa condition | Scoring criteria:
| Baseline, 1, 3 and 6 months. |
| Change in mucosal margin | Dichotomous scoring (migrated/non migrated) | Baseline, 1, 3 and 6 months. |
| Probing Pocket Depth | Evaluation (in mm) of the depth of the gingival sulcus, through a millimeter periodontal probe; it is detected from the gingival margin to the bottom of the gingival sulcus or periodontal pocket, evaluated at 6 sites. | Baseline, 1, 3 and 6 months. |
| Change in PI - Plaque Index (percentage) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Andrea Scribante, DDS, PhD. | University of Pavia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Unit of Dental Hygiene - Section of Dentistry - Department of Clinical, Surgical, Diagnostic and Paediatrics - University of Pavia | Pavia | Lombardy | 27100 | Italy |
Data will be available upon motivated request to Principal Investigator
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|
| Standard oral hygiene | Other | Use of standard toothpastes for home oral hygiene. |
|
Evaluation of the presence of plaque on the 4 surfaces of teeth on the total amount of dental surfaces. |
| Baseline, 1, 3 and 6 months. |
| Change in BS - Bleeding Score | Scoring criteria:
| Baseline, 1, 3 and 6 months. |
| ID | Term |
|---|---|
| D002710 | Chlorhexidine |
| ID | Term |
|---|---|
| D001645 | Biguanides |
| D006146 | Guanidines |
| D000578 | Amidines |
| D009930 | Organic Chemicals |
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