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This study aimed to investigate the impact of Physical therapy in adult patients receiving intensive induction chemotherapy for the treatment of acute leukemia during prolonged hospitalization. The study cohort included 150 patients. Primary objective is to compare the effect of a standardized rehabilitation program on physical deconditioning. This study has several secondary objectives of comparing and analyzing the status of sarcopenia, muscle strength, physical performance and the psychic dimension of this intervention. The 6 minutes walking test, Handgrip strength, impedance measurement, computed tomography, Short Physical Performance were used as measures of physical function. Hospital Anxiety and Depression Scale and European Organization for the Research and Treatment of Cancer-Quality of Life-Questionnaire-30 (EORTC-QLQ-30) were used as measures of depression and anxiety and quality of life of cancer patients. To investigate the impact of physical therapy, patients were assigned to the physical therapy group (experimental group) or the control group.These results will thus make it possible to promote access to physiotherapy and rehabilitation care, from diagnosis and during hospitalization, and to standardize practices.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control group | No Intervention | ||
| KinHémo group | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| KinHémo | Other | Evaluation and cardiovascular training, combination of resistance and flexibility training |
|
| Measure | Description | Time Frame |
|---|---|---|
| The distance covered over a time of 6 minutes is used as the outcome by which to compare changes in performance capacity between V1 and V0 | The six-minute walk test (6MWT) measures the distance an individual is able to walk over a total of six minutes on a hard, flat surface. The goal is for the individual to walk as far as possible in six minutes. | The distance covered over a time of 6 minutes is used as the outcome by which to compare changes in performance capacity between V1 and V0 |
| Measure | Description | Time Frame |
|---|---|---|
| The physical performance assessed with Evolution of Short Physical Performance Battery | Evolution of Short Physical Performance Battery measurements, | The worsening rate of sarcopenia defined either by the occurrence of a status of sarcopenia regardless of the stage or by moving from one sarcopenia stage's to another, 4 to 6 week after hospitalization |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Maria LUBI LEON | Contact | +33 6.67.94.14.68 | Maria.LubiLeon@chu-angers.fr | |
| Emma BLANCHET | Contact | +33 2 41 35 63 38 | EmBlanchet@chu-angers.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Angers | Recruiting | Angers | 49933 | France |
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| The muscle mass assessed with Bioelectrical impedance analysis | Evolution of muscle mass by Bioelectrical impedance analysis | The worsening rate of sarcopenia defined either by the occurrence of a status of sarcopenia regardless of the stage or by moving from one sarcopenia stage's to another, 4 to 6 week after hospitalization |
| Anxiety and Depressive Disorders assessed with the Hospital Anxiety and Depression Scale | Assessment of anxiety and depressive disorders | Hospital Anxiety and Depression Scale and European Organization for the Research |
| Evolution of activities of daily living assessed with Treatment of Cancer-Quality of Life Questionnaire-30 | Treatment of Cancer-Quality of Life Questionnaire-30 were used as measures of quality of life of cancer patients | The comparison visit 0 versus Visit 1 bis 10 to 15 days after discharge from hospital for induction |
| muscle strength assessed with dynamometer and standing up test chair | Evolution of muscle strength by measuring grip strength by dynamometer, evolution of the muscle strength of the lower limbs by standing up test chair | The worsening rate of sarcopenia defined either by the occurrence of a status of sarcopenia regardless of the stage or by moving from one sarcopenia stage's to another, 4 to 6 week after hospitalization |
| Rate of patients with at least one complication | The comparison of the effect of a standardized exercise therapy program versus practice current hospitalization for the induction phase of chemotherapy: Complications of all types (pressure sore, infection, stay in intensive care). | The rate of patients with at least one complication is used as the outcome by wich to compare of effect of a standardized exercise therapy program versus practice current after 4-6 weeks hospitalization |
| CHU Brest | Recruiting | Brest | France |
|
| CHU Nantes | Recruiting | Nantes | France |
|
| CHU Tours | Recruiting | Tours | France |
|
| ID | Term |
|---|---|
| D055948 | Sarcopenia |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D009133 | Muscular Atrophy |
| D020879 | Neuromuscular Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D001284 | Atrophy |
| D020763 | Pathological Conditions, Anatomical |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012816 | Signs and Symptoms |
| D001519 | Behavior |
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