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This study aimed to investigate whether femtosecond laser-assisted LASIK (FS-LASIK) surgery causes inflammation in the anterior chamber and to analyze its effect on endothelial cells.
Since FS-LASIK surgery is applied using both an FS laser and an excimer laser, we aimed to determine the direct and indirect effects of these applications on the corneal endothelium, the intensity of the inflammation, and the blood-aqueous barrier in the anterior chamber. To the best of our knowledge, the effects of FS-LASIK on anterior chamber inflammation have not been previously investigated. Therefore, we evaluated these effects using objective measurement methods, such as specular microscopy and laser flare photometry.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pre-surgery and post-surgery | Other | femtosecond assisted LASIK |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Femtosecond laser assisted LASIK | Procedure | Refractive surgery |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change of Flare Values | To measure anterior chamber inflammation objectively, Flare values were measured by the laser flare-photometry | The change of flare values on first day, seventh day, 1. month and 3. months according to preoperative values |
| Measure | Description | Time Frame |
|---|---|---|
| Change of Corneal endothelium features-1 | Endothelial cell density (ECD),(The parameter was measured by specular microscopy) | the changes of the parameters of preoperative and 3. months' values |
| Measure | Description | Time Frame |
|---|---|---|
| Change of Corneal endothelium features-2 | Coefficient of Varience (CV) in cell size, (The parameter was measured by specular microscopy) | the changes of the parameters of preoperative and 3. months' values |
| Change of Corneal endothelium features-3 |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Kemal Turgay Ozbilen, M.D. | Istanbul University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Istanbul Faculty of Medicine | Fatih | Istanbul | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34868671 | Derived | Ozbilen KT, Altinkurt E, Ceylan NA, Bilgin GS, Gozum N. Effect of Myopic Femtosecond Laser-Assisted LASIK on Anterior Chamber Inflammation (Flare Values) and Corneal Endothelium: A Prospective before and after Study. J Ophthalmol. 2021 Nov 26;2021:2395028. doi: 10.1155/2021/2395028. eCollection 2021. |
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prospective, before-after study
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Patients name and identifiers were masked
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Hexagonality percent of the cell shape. (The parameter was measured by specular microscopy)
| the changes of the parameters of preoperative and 3. months' values |
| ID | Term |
|---|---|
| D003316 | Corneal Diseases |
| ID | Term |
|---|---|
| D005128 | Eye Diseases |
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