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| Name | Class |
|---|---|
| Istinye University | OTHER |
| Liv Hospital (Ulus) | UNKNOWN |
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Our aim in this study is to determine the positive effect of stem cell therapy applied on critically ill patients with coronavirus infection on DNA repair genes.
Patients diagnosed with COVID-19 infection are divided into two equal (n:30) groups. Group-1(n/15): Patients in critically ill condition receiving conventional therapy, Group-2 (n/15): Patients in critically ill condition receiving conventional therapy and systemically transplanted MSCs. The DNA repair pathway will be examined as 11 genes in 5 different parts. Investigated parameters:
Our aim in this study is to determine the positive effect of stem cell therapy applied on critically ill patients with coronavirus infection on DNA repair genes.
Patients diagnosed with COVID-19 infection are divided into two equal (n:30) groups. Group-1(n/15): Patients in critically ill condition receiving conventional therapy, Group-2 (n/15): Patients in critically ill condition receiving conventional therapy and systemically transplanted MSCs. The DNA repair pathway will be examined as 11 genes in 5 different parts. Investigated parameters:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Conventional Therapy | Experimental |
| |
| Conventional Therapy with Add-On MSC therapy | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mesenchymal Stem Cells Transplantation | Biological | Mesenchymal Stem Cells Transplantation applied as three intravenous infusions with 30 days intervals |
|
| Measure | Description | Time Frame |
|---|---|---|
| Expression of PARP1 gene as indicator of base excision repair | Expression of PARP1 gene as indicator of base excision repair | 6 months |
| Expression of genes ATM, RAD51, RAD52 and WRN as indicator of Recombinational repair | Expression of genes ATM, RAD51, RAD52 and WRN as indicator of Recombinational repair | 6 months |
| Expression of genes RAD23B and ERCC1 as indicator of Nucleotide excision repair | Expression of genes RAD23B and ERCC1as indicator of Nucleotide excision repair | 6 months |
| Expression of genes MLH1, MSH2 and MSH6as indicator of Mismatch repair | Expression of genes MLH1, MSH2 and MSH6 as indicator of Mismatch repair | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
pregnant, malignant tumours, the ones who has confirmed co-infection; history of using long-term immunosuppressive agents
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Istinye University | Istanbul | 34010 | Turkey (Türkiye) | |||
| SBÜ Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi |
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| ID | Term |
|---|---|
| D000086382 | COVID-19 |
| ID | Term |
|---|---|
| D011024 | Pneumonia, Viral |
| D011014 | Pneumonia |
| D012141 | Respiratory Tract Infections |
| D007239 | Infections |
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| Istanbul |
| 34147 |
| Turkey (Türkiye) |
| D014777 |
| Virus Diseases |
| D018352 | Coronavirus Infections |
| D003333 | Coronaviridae Infections |
| D030341 | Nidovirales Infections |
| D012327 | RNA Virus Infections |
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |